Clinical and translational exploration of sensorineural hearing loss
Genetics and Physiology of Hearing, Paris
Fundamental questions that are essential for efficient hearing rehabilitation are addressed: how do auditory hair cells synapses and central synaptic connections evolve with aging, sound trauma and genetic neuropathies? The molecular changes occurring in auditory synaptic transmission are deciphered in mouse models. Methods of viral gene transfer are developped in order to rescue and reverse the synaptic defects.
Innovative techniques: cochlear viral gene transfer. gene editing. cochlear and hair cell electrophysiology.
Associated team from: Institut de l’Audition – Centre de l’Institut Pasteur – Inserm UA06
Mots clés
Selected publications
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Proof of concept of intracochlear drug administration by laser-assisted bioprinting in mice.
Manon Jaffredo, Océane Duchamp, Nicolas Touya, Yohan Bouleau, Didier Dulon, Raphael Devillard, Damien Bonnard.
Hearing Research. 2023-10-01. 438 : 108880.
DOI: 10.1016/j.heares.2023.108880 -
Synaptic Release Potentiation at Aging Auditory Ribbon Synapses
Thibault Peineau, Séverin Belleudy, Susanna Pietropaolo, Yohan Bouleau , Didier Dulon.
Front Aging Neurosci.. .
DOI: 10.3389/fnagi.2021.756449 -
Clustered Ca2+ Channels Are Blocked by Synaptic Vesicle Proton Release at Mammalian Auditory Ribbon Synapses
Philippe F.Y. Vincent, Soyoun Cho, Margot Tertrais, Yohan Bouleau, Henrique von Gersdorff, Didier Dulon.
Cell Reports. 2018-12-01. 25 (12) : 3451-3464.e3.
DOI: 10.1016/j.celrep.2018.11.072 -
Clarin-1 gene transfer rescues auditory synaptopathy in model of Usher syndrome
Didier Dulon, Samantha Papal, Pranav Patni, Matteo Cortese, Philippe F.Y. Vincent, Margot Tertrais, Alice Emptoz, Abdelaziz Tlili, Yohan Bouleau, Vincent Michel, Sedigheh Delmaghani, Alain Aghaie, Elise Pepermans, Olinda Alegria-Prevot, Omar Akil, Lawrence Lustig, Paul Avan, Saaid Safieddine, Christine Petit, Aziz El-Amraoui.
Journal of Clinical Investigation. 2018-07-09. 128 (8) : 3382-3401.
DOI: 10.1172/jci94351 -
Different CaV1.3 Channel Isoforms Control Distinct Components of the Synaptic Vesicle Cycle in Auditory Inner Hair Cells.
Philippe F.Y. Vincent, Yohan Bouleau, Gilles Charpentier, Alice Emptoz, Saaid Safieddine, Christine Petit, Didier Dulon.
J. Neurosci.. 2017-02-13. 37 (11) : 2960-2975.
DOI: 10.1523/jneurosci.2374-16.2017 -
A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells.
Philippe FY Vincent, Yohan Bouleau, Christine Petit, Didier Dulon.
eLife. 2015-11-14. 4
DOI: 10.7554/elife.10988
Team member(s)
Chercheurs, Praticiens hospitaliers...
Ingénieur(e)s, technicien(ne)s
Post-doctorant(s)
Doctorant(s)
Neuropsychologist(s) and speech therapist(s)
Ingénieur(s) hospitalier(s) et ARC
Adresse :
Hôpital Pellegrin Bat PQR3, 33076 Bordeaux