Dopamine and neuronal assemblies
Our laboratory examines the functions of the « extended basal ganglia network », a neuronal network composed of interconnected limbic and motor nuclei. We aim at characterizing this network at the synaptic level, focusing on how synaptic transmission and plasticity are controlled by dopamine. Our research will provide new understandings of physiological functions (voluntary movements, associative learning…) and of dopamine-associated disorders (Parkinson’s disease, addiction…).
Mots clés
Apprentissage, Assemblées neuronales, Bio-senseurs, Comportement, Connectivité, Dépression, Emotion, Excitabilité neuronale, Huntington, Imagerie cellulaire in vitro ou in vivo, Maladie de Huntington, Motivation, Motricité, Mouvement, Neurophysiologie, Optogénétique, Optogénétique et chemogénétique, Parkinson, Plasticité des réseaux, Plasticité synaptique, Stress, decision-makingSelected publications
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A population of Insula neurons encodes for social preference only after acute social isolation in mice
Christelle Glangetas, Adriane Guillaumin, Elodie Ladevèze, Anaelle Braine, Manon Gauthier, Léa Bonamy, Evelyne Doudnikoff, Thibault Dhellemmes, Marc Landry, Erwan Bézard, Stephanie Caille, Anne Taupignon, Jérôme Baufreton, François Georges.
Nat Commun. 2024-08-21. 15 (1)
DOI: 10.1038/s41467-024-51389-4 -
Emotion in action: When emotions meet motor circuits
Anaelle Braine, François Georges.
Neuroscience & Biobehavioral Reviews. 2023-12-01. 155 : 105475.
DOI: 10.1016/j.neubiorev.2023.105475 -
A role for the subthalamic nucleus in aversive learning
Gian Pietro Serra, Adriane Guillaumin, Bianca Vlcek, Lorena Delgado-Zabalza, Alessia Ricci, Eleonora Rubino, Sylvie Dumas, Jérôme Baufreton, François Georges, Åsa Wallén-Mackenzie.
Cell Reports. 2023-11-01. 42 (11) : 113328.
DOI: 10.1016/j.celrep.2023.113328 -
Targeting parvalbumin-expressing neurons in the substantia nigra pars reticulata restores motor function in parkinsonian mice
Lorena Delgado-Zabalza, Nicolas P. Mallet, Christelle Glangetas, Guillaume Dabee, Maurice Garret, Cristina Miguelez, Jérôme Baufreton.
Cell Reports. 2023-10-01. 42 (10) : 113287.
DOI: 10.1016/j.celrep.2023.113287 -
Spatiomolecular Characterization of Dopamine D2 Receptors Cells in the Mouse External Globus Pallidus
Julie Espallergues, Jihane Boubaker-Vitre, Audrey Mignon, Maelle Avrillon, Morgane Le Bon-Jego, Jerome Baufreton, Emmanuel Valjent.
CN. 2023-07-20. 21
DOI: 10.2174/1570159x21666230720121027 -
A non-canonical GABAergic pathway to the VTA promotes unconditioned freezing
Loïc Broussot, Thomas Contesse, Renan Costa-Campos, Christelle Glangetas, Léa Royon, Hugo Fofo, Thomas Lorivel, François Georges, Sebastian P. Fernandez, Jacques Barik.
Mol Psychiatry. 2022-09-20. 27 (12) : 4905-4917.
DOI: 10.1038/s41380-022-01765-7 -
Striatal circuit development and its alterations in Huntington’s disease
Margaux Lebouc, Quentin Richard, Maurice Garret, Jérôme Baufreton.
Neurobiology of Disease. 2020-09-01. : 105076.
DOI: 10.1016/j.nbd.2020.105076 -
Dysregulation of external globus pallidus‐subthalamic nucleus network dynamics in parkinsonian mice during cortical slow‐wave activity and activation
Ryan F. Kovaleski, Joshua W. Callahan, Marine Chazalon, David L. Wokosin, Jérôme Baufreton, Mark D. Bevan.
J Physiol. 2020-02-29.
DOI: 10.1113/JP279232 -
Dopamine D2 receptors modulate intrinsic properties and synaptic transmission of parvalbumin interneurons in the mouse primary motor cortex
Jeremy Cousineau, Lea Lescouzeres, Anne Taupignon, Lorena Delgado-Zabalza, Emmanuel Valjent, Jerome Baufreton, Morgane Le Bon-Jego.
. 2019-10-13.
DOI: 10.1101/802140 -
Cellular and Synaptic Dysfunctions in Parkinson’s Disease: Stepping out of the Striatum
Mallet, Delgado, Chazalon, Miguelez, Baufreton.
Cells. 2019-08-29. 8 (9) : 1005.
DOI: 10.3390/cells8091005 -
The motivation for exercise over palatable food is dictated by cannabinoid type-1 receptors.
Carolina Muguruza, Bastien Redon, Giulia R. Fois, Imane Hurel, Amandine Scocard, Claire Nguyen, Christopher Stevens, Edgar Soria-Gomez, Marjorie Varilh, Astrid Cannich, Justine Daniault, Arnau Busquets-Garcia, Teresa Pelliccia, Stéphanie Caillé, François Georges, Giovanni Marsicano, Francis Chaouloff.
JCI Insight. 2019-03-07. 4 (5)
DOI: 10.1172/jci.insight.126190 -
D5 dopamine receptors control glutamatergic AMPA transmission between the motor cortex and subthalamic nucleus
Lionel Froux, Morgane Le Bon-Jego, Cristina Miguelez, Elisabeth Normand, Stephanie Morin, Stéphanie Fioramonti, Massimo Barresi, Andreas Frick, Jerome Baufreton, Anne Taupignon.
Sci Rep. 2018-06-11. 8 (1)
DOI: 10.1038/s41598-018-27195-6 -
GAT-3 Dysfunction Generates Tonic Inhibition in External Globus Pallidus Neurons in Parkinsonian Rodents
Marine Chazalon, Elena Paredes-Rodriguez, Stéphanie Morin, Audrey Martinez, Sofia Cristóvão-Ferreira, Sandra Vaz, Ana Sebastiao, Aude Panatier, Eric Boué-Grabot, Cristina Miguelez, Jérôme Baufreton.
Cell Reports. 2018-05-01. 23 (6) : 1678-1690.
DOI: 10.1016/j.celrep.2018.04.014 -
Alteration of GABAergic neurotransmission in Huntington’s disease
Maurice Garret, Zhuowei Du, Marine Chazalon, Yoon H. Cho, Jérôme Baufreton.
CNS Neurosci Ther. 2018-02-21. 24 (4) : 292-300.
DOI: 10.1111/cns.12826 -
Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors.
A. C. Penn, C. L. Zhang, F. Georges, L. Royer, C. Breillat, E. Hosy, J. D. Petersen, Y. Humeau, D. Choquet.
Nature. 2017-09-13. 549 (7672) : 384-388.
DOI: 10.1038/nature23658 -
Species-specific diversity in the anatomical and physiological organisation of the BNST-VTA pathway.
Jennifer Kaufling, Delphine Girard, Marlène Maitre, Thierry Leste-Lasserre, François Georges.
Eur J Neurosci. 2017-03-28. 45 (9) : 1230-1240.
DOI: 10.1111/ejn.13554 -
NMDA-receptor-dependent plasticity in the bed nucleus of the stria terminalis triggers long-term anxiolysis.
Christelle Glangetas, Léma Massi, Giulia R. Fois, Marion Jalabert, Delphine Girard, Marco Diana, Keisuke Yonehara, Botond Roska, Chun Xu, Andreas Lüthi, Stéphanie Caille, François Georges.
Nat Comms. 2017-02-20. 8 : 14456.
DOI: 10.1038/ncomms14456 -
Opioid receptor gene expression in the rat brain during ontogeny, with special reference to the mesostriatal system: an in situ hybridization study.
Georges F1, Normand E, Bloch B, Le Moine C..
Brain Res Dev Brain Res.. 1998-08-08. 109 (2) : 187-99.
DOI: 10.1016/s0165-3806(98)00082-0
Team leader
Team member(s)
Chercheurs, Praticiens hospitaliers...
Morgane Le Bon-Jego
Le Bon-Jego
(University Teacher- Researcher)
Ingénieur(e)s, technicien(ne)s
Elodie Ladevèze
Ladevèze
Post-doctorant(s)
Christelle Glangetas
glangetas
Margaux Lebouc Lebouc
Adriane Guillaumin Guillaumin
Rodrigue Ortolé Ortolé
Alba Garcia Baos Garcia Baos
Teresa Sierra Sierra
Margaux Lebouc Lebouc
Adriane Guillaumin Guillaumin
Rodrigue Ortolé Ortolé
Alba Garcia Baos Garcia Baos
Teresa Sierra Sierra
Doctorant(s)
Léa Bonamy
Bonamy
Laura De Las Heras-Garcia De Las Heras-Garcia
Jakob Scharnholz Scharnholz
Viviana Villacaña-Muñoz Villacaña-Muñoz
Emma Perrot Perrot
Laura De Las Heras-Garcia De Las Heras-Garcia
Jakob Scharnholz Scharnholz
Viviana Villacaña-Muñoz Villacaña-Muñoz
Emma Perrot Perrot
Neuropsychologist(s) and speech therapist(s)
Ingénieur(s) hospitalier(s) et ARC