[How to define treatment-resistant depression?].
La Presse Médicale. 2016-03-01; 45(3): 323-328
DOI: 10.1016/j.lpm.2016.02.002
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1. Presse Med. 2016 Mar;45(3):323-8. doi: 10.1016/j.lpm.2016.02.002. Epub 2016
Mar 9.
[How to define treatment-resistant depression?].
[Article in French]
Holtzmann J(1), Richieri R(2), Saba G(3), Allaïli N(4), Bation R(5), Moliere
F(6), Nieto I(4), Bellivier F(4), Bennabi D(7), Bubrovszky M(8), Camus V(9),
Charpeaud T(10), Courvoisier P(11), Haesebaert F(5), Doumy O(12), Courtet P(6),
El-Hage W(9), Garnier M(10), d’Amato T(5), Lançon C(2), Leboyer M(3), Llorca
PM(10), Vaiva G(8), Bougerol T(11), Aouizerate B(12), Haffen E(7).
Author information:
(1)CHU de Grenoble, hôpital Nord, centre expert dépression résistante
fondamental, service de psychiatrie de l’adulte, CS 10217, 38043 Grenoble cedex
9, France. Electronic address: .
(2)CHU La-Conception, pôle psychiatrie centre, centre expert dépression
résistante fondamental, 13005 Marseille, France.
(3)Hôpital Chenevier, Henri-Mondor, pôle de psychiatrie des hôpitaux
universitaires, centre expert dépression résistante fondamental, 94000 Créteil,
France.
(4)Hôpital Fernand-Widal, centre expert dépression résistante fondamental,
service de psychiatrie adulte, 75010 Paris, France.
(5)Centre hospitalier Le-Vinatier, centre expert dépression résistante
fondamental, service universitaire de psychiatrie adulte, BP 300 39, 69678 Bron
cedex, France.
(6)CHRU Lapeyronie, centre expert dépression résistante fondamental, département
des urgences et post-urgences psychiatrique, 34295 Montpellier cedex 5, France.
(7)CHU de Besançon, centre expert dépression résistante fondamental, service de
psychiatrie de l’adulte, 25030 Besançon cedex, France.
(8)CHRU de Lille, hôpital Fontan 1, centre expert dépression résistante
fondamental, service de psychiatrie adulte, 59037 Lille cedex, France.
(9)CHU de Tours, clinique psychiatrique universitaire, centre expert dépression
résistante fondamental, 37044 Tours cedex 9, France.
(10)CHU de Clermont-Ferrand, centre expert dépression résistante fondamental,
service de psychiatrie de l’adulte B, 63003 Clermont-Ferrand, France.
(11)CHU de Grenoble, hôpital Nord, centre expert dépression résistante
fondamental, service de psychiatrie de l’adulte, CS 10217, 38043 Grenoble cedex
9, France.
(12)CH Charles-Perrens, centre expert dépression résistante fondamental, pôle de
psychiatrie générale et universitaire, 33076 Bordeaux cedex, France.
The most largely used definition of the treatment-resistant depression relies on
the failure of two successive trials of antidepressant treatment at an adequate
dose and duration. The absence of response to previous antidepressant treatments
should be assessed using specific and appropriate clinical instruments enabling
a correct staging of the therapeutic resistance. A wide range of
socio-demographic and clinical factors (i.e. psychiatric/somatic comorbidities)
are classically associated with the therapeutic resistance. The aim of the
treatment of major depression is to achieve a complete clinical remission. The
presence of residual symptoms increases the risk for the subsequent occurrence
of relapses and recurrences, hence facilitating the development of therapeutic
resistance. The treatment-resistant depression has a deleterious impact on the
social, familial or professional functioning, thereby leading to an impaired
quality of life with serious socioeconomic consequences and costs.
Copyright © 2016. Published by Elsevier Masson SAS.
DOI: 10.1016/j.lpm.2016.02.002
PMID: 26970938 [Indexed for MEDLINE]