Childhood maltreatment and metabolic syndrome in bipolar disorders: In search of moderators.
Psychoneuroendocrinology. 2021-09-01; 131: 105327
DOI: 10.1016/j.psyneuen.2021.105327
Read on PubMed
1. Psychoneuroendocrinology. 2021 Sep;131:105327. doi:
10.1016/j.psyneuen.2021.105327. Epub 2021 Jun 15.
Childhood maltreatment and metabolic syndrome in bipolar disorders: In search of
moderators.
Godin O(1), Gaube G(2), Olié E(3), Belzeaux R(4), Bellivier F(5), Loftus J(6),
Courtet P(3), Dubertret C(7), Llorca PM(8), Gard S(9), Henry C(10), Schwan
R(11), Passerieux C(12), Polosan M(13), Samalin L(8), Leboyer M(14), Etain B(5);
FondaMental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD)
Collaborators.
Collaborators: Etain B(15), Henry C(16), Olié E(17), Leboyer M(16), Haffen
E(16), Llorca PM(16), Barteau V(18), Bensalem S(18), Godin O(18), Laouamri
H(18), Souryis K(18), Hotier S(19), Pelletier A(19), Drancourt N(19), Sanchez
JP(19), Saliou E(19), Hebbache C(19), Petrucci J(19), Willaume L(19), Bourdin
E(19), Bellivier F(20), Carminati M(20), Etain B(20), Marlinge E(20), Meheust
J(20), Meyrel M(20), Aouizerate B(21), Desage A(21), Gard S(21), Sportich J(21),
Mbailara K(21), Minois I(21), Zanouy L(21), Bardin L(22), Cazals A(22), Courtet
P(22), Deffinis B(22), Ducasse D(22), Gachet M(22), Henrion A(22), Moliere
F(22), Noisette B(22), Olie E(22), Tarquini G(22), Belzeaux R(23), Correard
N(23), Groppi F(23), Lefrere A(23), Lescalier L(23), Moreau E(23), Pastol J(23),
Rebattu M(23), Roux B(23), Viglianese N(23), Cohen R(24), Schwan R(24), Kahn
JP(24), Milazzo M(24), Wajsbrot-Elgrabli O(24), Bougerol T(25), Fredembach
B(25), Suisse A(25), Halili B(25), Pouchon A(25), Polosan M(25), Galliot AM(26),
Grévin I(26), Cannavo AS(26), Kayser N(26), Passerieux C(26), Roux P(26),
Service de Psychiatrie(26), Aubin V(27), Cussac I(27), Dupont MA(27), Loftus
J(27), Medecin I(27), Dubertret C(28), Mazer N(28), Portalier C(28),
Scognamiglio C(28), Bing A(28).
Author information:
(1)Fondation FondaMental, Créteil, France; Univ Paris Est Créteil, INSERM, IMRB,
Translational Neuropsychiatry, AP-HP, DMU IMPACT, FHU ADAPT, Fondation
FondaMental, F-94010 Créteil, France. Electronic address:
.
(2)APHP, Sorbonne Université, Département Medico-Universitaire Neurosciences,
Unité de Psychiatrie, Psychotraumatologie et Addictions, Hôpital Tenon, Paris,
France.
(3)Fondation FondaMental, Créteil, France; Department of Emergency Psychiatry
and Acute Care, Lapeyronie Hospital, CHU Montpellier, Montpellier, France;
PSNREC, Univ Montpellier, INSERM, CHU Montpellier, Montpellier, France.
(4)Fondation FondaMental, Créteil, France; Pôle de Psychiatrie, Assistance
Publique Hôpitaux de Marseille, Marseille, France; INT-UMR7289, CNRS
Aix-Marseille Université, Marseille, France.
(5)Fondation FondaMental, Créteil, France; Assistance Publique des Hôpitaux de
Paris (AP-HP) Paris. Nord, GHU Saint-Louis – Lariboisière – Fernand Widal, DMU
Neurosciences, Département de Psychiatrie et de Médecine Addictologique, INSERM
UMRS 1144, Université de Paris, Paris, France.
(6)Fondation FondaMental, Créteil, France; Pôle de Psychiatrie, Centre
Hospitalier Princesse Grace, Monaco, France.
(7)Fondation FondaMental, Créteil, France; AP-HP, Groupe Hospitalo-universitaire
Nord, DMU ESPRIT, service de Psychiatrie et Addictologie, Hopital Louis Mourier,
Colombes, Inserm U1266, Faculté de médecine, Université de Paris, France.
(8)Fondation FondaMental, Créteil, France; CHU Clermont-Ferrand, Department of
Psychiatry, University of Clermont Auvergne, EA7280, Clermont-Ferrand, France.
(9)Fondation FondaMental, Créteil, France; Centre Expert Troubles Bipolaires,
Service de Psychiatrie Adulte, Hôpital Charles-Perrens, Bordeaux, France.
(10)Department of Psychiatry, Service Hospitalo-Universitaire, GHU Paris
Psychiatrie & Neuroscience, F-75014 Paris, France.
(11)Fondation FondaMental, Créteil, France; Université de Lorraine, Inserm
U1114, Centre Psychothérapique de Nancy, Nancy, France.
(12)Fondation FondaMental, Créteil, France; Service Universitaire de Psychiatrie
d’Adultes, Centre Hospitalier de Versailles, Le Chesnay, Service Universitaire
de Psychiatrie d’Adultes, Centre Hospitalier de Versailles, Le
Chesnay,Université Paris-Saclay, UVSQ, Inserm, CESP, Team “DevPsy”, 94807
Villejuif, France.
(13)Fondation FondaMental, Créteil, France; Université Grenoble Alpes, CHU de
Grenoble et des Alpes, Grenoble Institut des Neurosciences (GIN) Inserm U 1216,
Grenoble, France.
(14)Fondation FondaMental, Créteil, France; Univ Paris Est Créteil, INSERM,
IMRB, Translational Neuropsychiatry, AP-HP, DMU IMPACT, FHU ADAPT, Fondation
FondaMental, F-94010 Créteil, France.
(15)FACE-BD Clinical Coordinating Center (Fondation FondaMental), France;
FACE-BD Clinical Sites and Principal Collaborators in France, France; AP-HP, GH
Saint-Louis-Lariboisière-Fernand Widal, Pôle Neurosciences, Paris, France.
(16)FACE-BD Clinical Coordinating Center (Fondation FondaMental), France;
FACE-BD Clinical Sites and Principal Collaborators in France, France.
(17)FACE-BD Clinical Coordinating Center (Fondation FondaMental), France;
FACE-BD Clinical Sites and Principal Collaborators in France, France;
Département d’Urgence et Post Urgence Psychiatrique, CHRU Montpellier,
Montpellier, France.
(18)FACE-BD Clinical Sites and Principal Collaborators in France, France;
FACE-BD Data Coordinating Center (Fondation FondaMental), France.
(19)FACE-BD Clinical Sites and Principal Collaborators in France, France; AP-HP,
DHU PePSY, Pôle de Psychiatrie et d’Addictologie des Hôpitaux Universitaires H
Mondor, Créteil, France.
(20)FACE-BD Clinical Sites and Principal Collaborators in France, France; AP-HP,
GH Saint-Louis-Lariboisière-Fernand Widal, Pôle Neurosciences, Paris, France.
(21)FACE-BD Clinical Sites and Principal Collaborators in France, France;
Hôpital C. Perrens, Centre Expert Trouble Bipolaire, Service de Psychiatrie
Adulte, Pôle 3-4-7, Bordeaux, France.
(22)FACE-BD Clinical Sites and Principal Collaborators in France, France;
Département d’Urgence et Post Urgence Psychiatrique, CHRU Montpellier,
Montpellier, France.
(23)FACE-BD Clinical Sites and Principal Collaborators in France, France; Pôle
de Psychiatrie, addictologie et pédopsychiatrie, Hôpital Sainte Marguerite,
Marseille, France.
(24)FACE-BD Clinical Sites and Principal Collaborators in France, France;
Service de Psychiatrie et Psychologie Clinique, CHU de Nancy, Hôpitaux de
Brabois, Vandoeuvre Les Nancy, France.
(25)FACE-BD Clinical Sites and Principal Collaborators in France, France;
Service Universitaire de Psychiatrie, CHU de Grenoble et des Alpes, Grenoble,
France.
(26)FACE-BD Clinical Sites and Principal Collaborators in France, France; Centre
Hospitalier de Versailles, Service Universitaire de Psychiatrie d’adultes, Le
Chesnay, France.
(27)FACE-BD Clinical Sites and Principal Collaborators in France, France;
Service de Psychiatrie Centre Hospitalier Princesse Grace, Monaco, France.
(28)FACE-BD Clinical Sites and Principal Collaborators in France, France;
Service de psychiatrie et addictologie, Hôpital Louis Mourier, Colombes, AP-HP
Nord, France.
As compared to the general population, adult individuals with bipolar disorders
(BD) have higher mortality rates due to cardiovascular diseases and higher
prevalence of Metabolic Syndrome (MetS). Recent evidence suggests that childhood
maltreatment may contribute to the cardiovascular burden in individuals with BD.
However, studies are scarce, with limited sample sizes and inconsistent results.
We explored the associations between a self-reported history of childhood
maltreatment and MetS (and its subcomponents) in a large sample of 2390
individuals with BD. Childhood maltreatment was assessed using the Childhood
Trauma Questionnaire and MetS was defined according to the revised criteria of
the ATEP III. We suggested associations between childhood maltreatment and the
presence of MetS in men and in younger individuals. The association between
childhood maltreatment and the presence of MetS in the early onset subgroup was
not significant after adjustment for site of recruitment and level of education.
Hence, some links between childhood maltreatment and MetS might exist only in
specific subgroups of individuals with BD, but confirmation is required in
independent and large samples, while taking into account potential confounders.
This would help defining how psychosocial interventions that target childhood
maltreatment and its consequences may be beneficial for physical health.
Copyright © 2021. Published by Elsevier Ltd.
DOI: 10.1016/j.psyneuen.2021.105327
PMID: 34182249 [Indexed for MEDLINE]