Relationship between neurocognition and theory of mind as a function of symptomatic profile in schizophrenia: results from the national FACE-SZ cohort.
Cognitive Neuropsychiatry. 2021-12-09; 27(1): 49-68
DOI: 10.1080/13546805.2021.2011184
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1. Cogn Neuropsychiatry. 2022 Jan;27(1):49-68. doi:
10.1080/13546805.2021.2011184. Epub 2021 Dec 9.
Relationship between neurocognition and theory of mind as a function of
symptomatic profile in schizophrenia: results from the national FACE-SZ cohort.
Rambeau S(1), Del Goleto S(1), Pignon B(1), Lajnef M(1), Petrucci J(1), Szöke
A(1), Fond G(2), Lançon C(2), Dorey JM(3), Rey R(3), Garbisson A(4), Capdevielle
D(4), Leignier S(5), Dubreucq J(5), Mallet J(6)(7), Dubertret C(6)(7), Urbach
M(8)(9), Brunet-Gouet E(8)(9), Aouizerate B(10)(11), Misdrahi D(10)(11),
Zinetti-Bertschy A(12), Clauss J(12), Llorca PM(13), Chereau I(13); Members of
the FACE-SZ group; Leboyer M(1), Roux P(8)(9), Schürhoff F(1).
Author information:
(1)Université Paris Est Créteil (UPEC), AP-HP, Hôpitaux Universitaires « H.
Mondor », DMU IMPACT, INSERM, IMRB, Neuropsychiatrie translationnelle, Fondation
FondaMental, Créteil, France.
(2)AP-HM, Université Aix-Marseille, Ecole de médecine – La Timone Medical
Campus, EA 3279: CEReSS – Centre d’Études et de Recherche sur les Services de
Santé et la Qualité de Vie, Marseille, France.
(3)INSERM U1028, CNRS UMR5292, Centre de Recherche en Neurosciences de Lyon,
Université Claude Bernard Lyon 1, Equipe PSYR2, Centre Hospitalier Le Vinatier,
Pole Est, Bron Cedex, France.
(4)Service Universitaire de Psychiatrie Adulte, Hôpital la Colombière, CHRU
Montpellier, Université Montpellier 1, Inserm 1061, Montpellier, France.
(5)Centre Référent de Réhabilitation Psychosociale et de Remédiation Cognitive
(C3R), CH Alpes Isère, France.
(6)AP-HP, Groupe Hospitalo-Universitaire AP-HP Nord, service de Psychiatrie et
Addictologie. Hôpital Louis Mourier, Colombes, France.
(7)Université de Paris, INSERM UMR1266, Institut de Psychiatrie et Neurosciences
de Paris, Paris, France.
(8)Service Universitaire de Psychiatrie d’Adultes et d’Addictologie, Centre
Hospitalier de Versailles, Le Chesnay, France.
(9)DisAP-DevPsy-CESP, INSERM UMR1018, Université Paris-Saclay, Université
Versailles Saint-Quentin-En-Yvelines, Villejuif, France.
(10)Centre Hospitalier Charles Perrens, Université de Bordeaux, Bordeaux,
France.
(11)INRA, NutriNeuro, Université de Bordeaux, U1286, Bordeaux, France.
(12)Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, INSERM
U1114, Fédération de Médecine Translationnelle de Strasbourg, Strasbourg,
France.
(13)CHU Clermont-Ferrand, Département de Psychiatrie, Université de Clermont
Auvergne, EA 7280, Clermont-Ferrand, France.
INTRODUCTION: Deficits in theory of mind (ToM) can vary depending on the
predominant schizophrenia symptoms, and though most neurocognitive functions are
involved in ToM, all may not be associated with the same symptoms. With
consideration to the relationships between symptoms, neurocognition and ToM, the
aim of the present study is to identify the neurocognitive functions influencing
ToM capacities according to symptomatic profile.
METHODS: The study is based on a sample of 124 adults with schizophrenia from a
French national cohort. Patients were divided into two groups according to their
scores on the five Wallwork factors of the Positive and Negative Syndrome Scale
using hierarchical clustering before carrying out multivariable analyses.
RESULTS: The “disorganised group” (n = 89) showed high scores on the
disorganised factor, and had a ToM associated with reasoning, visual recognition
and speed of processing. The “positive group” (n = 35) showed high scores on the
positive and depressive factors, and had a ToM associated with working memory.
CONCLUSIONS: These results suggest that neurocognitive predictors of ToM in
schizophrenia are different according to the predominant clinical dimension,
thus refining our knowledge of the relationship between symptoms, neurocognition
and ToM, and acknowledging their status as important predictors of patients’
functional status.
DOI: 10.1080/13546805.2021.2011184
PMID: 34882065 [Indexed for MEDLINE]