Association between the indole pathway of tryptophan metabolism and subclinical depressive symptoms in obesity: a preliminary study.
Int J Obes. 2022-01-10; 46(4): 885-888
DOI: 10.1038/s41366-021-01049-0
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1. Int J Obes (Lond). 2022 Apr;46(4):885-888. doi: 10.1038/s41366-021-01049-0.
Epub 2022 Jan 10.
Association between the indole pathway of tryptophan metabolism and subclinical
depressive symptoms in obesity: a preliminary study.
Delgado I(1), Cussotto S(1), Anesi A(2), Dexpert S(1), Aubert A(1), Aouizerate
B(1)(3), Beau C(4), Forestier D(5), Ledaguenel P(4), Magne E(4), Mattivi
F(2)(6), Capuron L(7).
Author information:
(1)University of Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR, 1286, Bordeaux,
France.
(2)Department of Food Quality and Nutrition, Research and Innovation Centre,
Fondazione Edmund Mach (FEM), San Michele all’Adige, Italy.
(3)Centre de référence régional des pathologies anxieuses et dépressives, CH
Charles Perrens, Pôle de Psychiatrie Générale et Universitaire, Bordeaux,
France.
(4)Service de Chirurgie Digestive et Pariétale, Clinique Jean Villar, Bruges,
France.
(5)Service de Chirurgie Digestive et Pariétale, Clinique Tivoli, Bordeaux,
France.
(6)Department of Cellular, Computational and Integrative Biology (CIBIO),
University of Trento, Trento, Italy.
(7)University of Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR, 1286, Bordeaux,
France. .
Converging data support the role of chronic low-grade inflammation in depressive
symptomatology in obesity. One mechanism likely to be involved relies on the
effects of inflammation on tryptophan (TRP) metabolism. While recent data
document alterations in the indole pathway of TRP metabolism in obesity, the
relevance of this mechanism to obesity-related depressive symptoms has not been
investigated. The aim of this preliminary study was to assess the association
between plasma levels of TRP and indole metabolites and depressive symptoms in
44 subjects with severe or morbid obesity, free of clinically relevant
neuropsychiatric disorders. The interaction effect of inflammation, reflected in
serum high-sensitive C-reactive protein (hsCRP) levels, and indoles on
depressive symptoms was also determined. Higher serum levels of hsCRP and lower
concentrations of TRP and indoles, particularly indole-3-carboxaldehyde (IAld),
correlated with more severe depressive symptoms. Interestingly, the effect of
high hsCRP levels in predicting greater depressive symptoms was potentiated by
low IAld levels. These results comfort the link between inflammation, the indole
pathway of TRP metabolism, and obesity-related depressive symptoms.
© 2021. The Author(s), under exclusive licence to Springer Nature Limited.
DOI: 10.1038/s41366-021-01049-0
PMID: 35001078 [Indexed for MEDLINE]