Double dissociation between actions of dopamine D1 and D2 receptors of the ventral and dorsolateral striatum to produce reinstatement of cocaine seeking behavior

Campos RC(1), Dias C(2), Darlot F(1), Cador M(3).

Author information:
(1)Université de Bordeaux, F-33076, Bordeaux, France; CNRS, Institut de
Neurosciences Cognitives et Intégratives d’Aquitaine, UMR 5287, Bordeaux,
France.
(2)Université de Bordeaux, F-33076, Bordeaux, France.
(3)Université de Bordeaux, F-33076, Bordeaux, France; CNRS, Institut de
Neurosciences Cognitives et Intégratives d’Aquitaine, UMR 5287, Bordeaux,
France. Electronic address: .

One of the hallmarks of addiction is the enduring vulnerability to relapse.
Following repeated use, cocaine (COC) induces neuroadaptations within the
dopamine (DA) system, arguably underlying several aspects of COC-seeking
behavior. Peripheral stimulation of D2, but not D1, receptors induces relapse.
However, where in the brain these effects occur is still matter of debate. The
D1 and D2 receptors (D1R; D2R) are highly expressed in the nucleus accumbens
(NAcc) and the dorsolateral striatum (DLS), but their specific involvement in
the reinstatement of COC-seeking remains elusive. We assessed the reinstating
effects of intracerebral infusions of agonists of D1R (SKF82958) or D2R
(quinelorane) within the NAcc or DLS of rats after extinction of COC
self-administration (COC SA). To assess whether we could block peripheral D2
agonist (quinelorane) induced reinstatement, we simultaneously infused either a
D1R (SCH23390) or a D2R (raclopride) antagonist within the NAcc or DLS. When
infused into the NAcc, but not into the DLS, SKF82958 induced reinstatement of
COC-seeking; conversely, quinelorane had no effect when injected into the NAcc,
but induced reinstatement when infused into the DLS while the D1R agonist has no
effect. While administration of raclopride into the NAcc or DLS impedes the
reinstating effect of a systemic quinelorane injection, the infusion of SCH23390
into the NAcc or DLS surprisingly, blocks the reinstatement induced by the
peripheral D2R stimulation. Our results point to a double dissociation between
D1R and D2R of the NAcc and DLS, highlighting their complex interactions within
both structures, in the reinstatement of COC-seeking behavior.

Copyright © 2020. Published by Elsevier Ltd.

DOI: 10.1016/j.neuropharm.2020.108113
PMID: 32335152 [Indexed for MEDLINE]

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