Addiction, interoception and sex differences (NEED)
For decades, neurosciences research was exclusively on males with the assumption that biological processes are the same across sexes. This dogma created a huge gap in our understanding of behavioral and brain mechanisms in both sexes. Although the field proved that this dogma is not always true, it left an important question unanswered: Why males and females have different vulnerability to brain disorders?
Drug addiction is among the disorders with the highest men/women prevalence ratio. While the prevalence is higher in men, the gap between men and women is narrowing highlighting that drug addiction affects both sexes. Clinical and preclinical studies report that both males and females have different vulnerability profiles to drug–related behaviors, however the underlying brain mechanisms are still poorly understood.
Our research program aims to decipher the behavioral mechanisms and neuronal circuits alterations that control sex differences in drug relapse in rodents. We will focus on understanding how environmental and interoceptive cues interact and trigger drug relapse in a sex–dependent manner and the contribution of the hormonal cycle in this phenomenon. To achieve this goal, we will use state–of–the–art model of drug addiction combined with cutting–edge technologies allowing the mapping, manipulation, imaging and recording of selective neural populations
Mots clés
Codage et intégration du signal, Cognition, Connectivité, Environnement, Motivation, Neuroadaptations, Neurophysiologie, Troubles addictifs, dimorphisme sexuel, hormones ovariennes, progestéroneSelected publications
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Dissociation Between Incubation of Cocaine Craving and Anxiety-Related Behaviors After Continuous and Intermittent Access Self-Administration
Celine Nicolas, Trinity I. Russell, Yavin Shaham, Satoshi Ikemoto.
Front. Neurosci.. 2022-02-07. 15
DOI: 10.3389/fnins.2021.824741 -
Linking emotional valence and anxiety in a mouse insula-amygdala circuit
Céline Nicolas, Anes Ju, Yifan Wu, Hazim Eldirdiri, Sebastien Delcasso, Débora Jacky, Laura Supiot, Claudia Fornari, Adrien Vérité, Maxime Masson, Silvia Rodriguez-Rozada, J. Simon Wiegert, Anna Beyeler.
Nature communications. 2023-08-21.
DOI: 10.1038/s41467-023-40517-1 -
Sex differences in opioid and psychostimulant craving and relapse: a critical review
Céline Nicolas, Natalie E. Zlebnik, Mehdi Farokhnia, Lorenzo Leggio, Satoshi Ikemoto, Yavin Shaham.
prePrint. 2021-03-31.
DOI: 10.1101/2021.03.30.21254644 -
Time-dependent regulation of perineuronal nets in the cerebellar cortex during abstinence of cocaine-self administration.
Aitor Sanchez-Hernandez, Celine Nicolas, Isis Gil-Miravet, Julian Guarque-Chabrera, Marcello Solinas, Marta Miquel.
Psychopharmacology. 2021-01-03. 238 (4) : 1059-1068.
DOI: 10.1007/s00213-020-05752-0 -
Incubation of Cocaine Craving After Intermittent-Access Self-administration: Sex Differences and Estrous Cycle.
Céline Nicolas, Trinity I. Russell, Anne F. Pierce, Steeve Maldera, Amanda Holley, Zhi-Bing You, Margaret M. McCarthy, Yavin Shaham, Satoshi Ikemoto.
Biological Psychiatry. 2019-06-01. 85 (11) : 915-924.
DOI: 10.1016/j.biopsych.2019.01.015 -
Generalization of effects of environmental enrichment on seeking for different classes of drugs of abuse.
Magdalena Sikora, Céline Nicolas, Marine Istin, Nematollah Jaafari, Nathalie Thiriet, Marcello Solinas.
Behavioural Brain Research. 2018-04-01. 341 : 109-113.
DOI: 10.1016/j.bbr.2017.12.027 -
Longitudinal Changes in Brain Metabolic Activity after Withdrawal from Escalation of Cocaine Self-Administration.
Céline Nicolas, Clovis Tauber, François-Xavier Lepelletier, Sylvie Chalon, Pauline Belujon, Laurent Galineau, Marcello Solinas.
Neuropsychopharmacol. 2017-05-29. 42 (10) : 1981-1990.
DOI: 10.1038/npp.2017.109 -
Interaction of chronic food restriction and methylphenidate in sensation seeking of rats.
Aleksandr D. Talishinsky, Celine Nicolas, Satoshi Ikemoto.
Psychopharmacology. 2017-04-08. 234 (14) : 2197-2206.
DOI: 10.1007/s00213-017-4625-6 -
Exposure to sucrose during periods of withdrawal does not reduce cocaine-seeking behavior in rats.
Céline Nicolas, Claire Lafay-Chebassier, Marcello Solinas.
Sci Rep. 2016-03-21. 6 (1)
DOI: 10.1038/srep23272 -
Statins Reduce the Risks of Relapse to Addiction in Rats.
Claudia Chauvet, Celine Nicolas, Claire Lafay-Chebassier, Mohamed Jaber, Nathalie Thiriet, Marcello Solinas.
Neuropsychopharmacol. 2015-10-15. 41 (6) : 1588-1597.
DOI: 10.1038/npp.2015.317 -
Prenatal exposure to methylphenidate affects the dopamine system and the reactivity to natural reward in adulthood in rats.
François-Xavier Lepelletier, Clovis Tauber, Céline Nicolas, Marcello Solinas, Pierre Castelnau, Catherine Belzung, Patrick Emond, Samuele Cortese, Stephen V. Faraone, Sylvie Chalon, Laurent Galineau.
International Journal of Neuropsychopharmacology. 2015-01-22. 18 (4)
DOI: 10.1093/ijnp/pyu044 -
Chronic stimulation of the tone of endogenous anandamide reduces cue- and stress-induced relapse in rats.
Claudia Chauvet, Céline Nicolas, Nathalie Thiriet, MD; Virginie Lardeux, Andrea Duranti, Marcello Solinas.
International Journal of Neuropsychopharmacology. 2014-12-19. 18 (1)
DOI: 10.1093/ijnp/pyu025 -
Medial prefrontal cortex and anteromedial thalamus interaction regulates goal-directed behavior and dopaminergic neuron activity.
Chen Yang, Yuzheng Hu, Aleksandr D. Talishinsky, Christian T. Potter, Coleman B. Calva, Leslie A. Ramsey, Andrew J. Kesner, Reuben F. Don, Sue Junn, Aaron Tan, Anne F. Pierce, Céline Nicolas, Yosuke Arima, Seung-Chan Lee, Conghui Su, Jensine M. Coudriet, Carlos A. Mejia-Aponte, Dong V. Wang, Hanbing Lu, Yihong Yang, Satoshi Ikemoto.
Nat Commun. 2022-03-16. 13 (1)
DOI: 10.1038/s41467-022-28892-7
Team member(s)
Chercheurs, Praticiens hospitaliers...
Ingénieur(e)s, technicien(ne)s
Post-doctorant(s)
Doctorant(s)
Neuropsychologist(s) and speech therapist(s)
Ingénieur(s) hospitalier(s) et ARC