Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors
Nat Neurosci. 2004-06-20; 7(7): 695-696
DOI: 10.1038/nn1270
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1. Nat Neurosci. 2004 Jul;7(7):695-6. Epub 2004 Jun 20.
Differential activity-dependent regulation of the lateral mobilities of AMPA and
NMDA receptors.
Groc L(1), Heine M, Cognet L, Brickley K, Stephenson FA, Lounis B, Choquet D.
Author information:
(1)UMR 5091 CNRS-Université Bordeaux 2, Bordeaux 33077, France.
The basis for differences in activity-dependent trafficking of AMPA receptors
(AMPARs) and NMDA receptors (NMDARs) remains unclear. Using single-molecule
tracking, we found different lateral mobilities for AMPARs and NMDARs: changes in
neuronal activity modified AMPAR but not NMDAR mobility, whereas protein kinase C
activation modified both. Differences in mobility were mainly detected for
extrasynaptic AMPARs, suggesting that receptor diffusion between synaptic and
extrasynaptic domains is involved in plasticity processes.
DOI: 10.1038/nn1270
PMID: 15208630 [Indexed for MEDLINE]