Two critical brain networks for generation and combination of remote associations
Brain. 2017-11-22; 141(1): 217-233
DOI: 10.1093/brain/awx294
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1. Brain. 2018 Jan 1;141(1):217-233. doi: 10.1093/brain/awx294.
Two critical brain networks for generation and combination of remote
associations.
Bendetowicz D(1)(2), Urbanski M(1)(3)(4), Garcin B(1)(2), Foulon C(1)(4), Levy
R(1)(2), Bréchemier ML(1), Rosso C(5)(6), Thiebaut de Schotten M(1)(4), Volle
E(1)(4).
Author information:
(1)Sorbonne Universités, UPMC Univ Paris 06, Inserm, CNRS, Institut du cerveau et
la moelle épinière (ICM) – FrontLab, Hôpital Pitié-Salpêtrière, Boulevard de
l’hôpital, F-75013, Paris, France.
(2)Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Neurology
Department, 75013 Paris, France.
(3)Hôpitaux de Saint-Maurice, Medicine and Rehabilitation Department, 94410
Saint-Maurice, France.
(4)Institut du cerveau et la moelle épinière (ICM), Brain Connectivity and
Behaviour group, 75013 Paris, France.
(5)Institut du cerveau et la moelle épinière (ICM), CENIR, 75013 Paris, France.
(6)Assistance Publique-Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Urgences
cérébro-Vasculaires, 75013 Paris, France.
Recent functional imaging findings in humans indicate that creativity relies on
spontaneous and controlled processes, possibly supported by the default mode and
the fronto-parietal control networks, respectively. Here, we examined the ability
to generate and combine remote semantic associations, in relation to creative
abilities, in patients with focal frontal lesions. Voxel-based lesion-deficit
mapping, disconnection-deficit mapping and network-based lesion-deficit
approaches revealed critical prefrontal nodes and connections for distinct
mechanisms related to creative cognition. Damage to the right medial prefrontal
region, or its potential disrupting effect on the default mode network, affected
the ability to generate remote ideas, likely by altering the organization of
semantic associations. Damage to the left rostrolateral prefrontal region and its
connections, or its potential disrupting effect on the left fronto-parietal
control network, spared the ability to generate remote ideas but impaired the
ability to appropriately combine remote ideas. Hence, the current findings
suggest that damage to specific nodes within the default mode and fronto-parietal
control networks led to a critical loss of verbal creative abilities by altering
distinct cognitive mechanisms.
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DOI: 10.1093/brain/awx294
PMID: 29182714 [Indexed for MEDLINE]