Physical activity, biomarkers of brain pathologies and dementia risk: Results from the Memento clinical cohort
Alzheimer's & Dementia. 2023-07-08; :
DOI: 10.1002/alz.13360
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Grasset L(1), Planche V(2), Bouteloup V(1)(3), Azouani C(4), Dubois B(5), Blanc F(6), Paquet C(7), David R(8), Belin C(9), Jonveaux T(10), Julian A(11)(12), Pariente J(13)(14), Mangin JF(4)(15), Chêne G(1)(3), Dufouil C(1)(3); Memento Cohort Study Group.
Collaborators: Allard M, Andrieu S, Anthony P, Astier C, Augier A, Auguste N,
Auriacombe S, Avet J, Bailon O, Barral FG, Barré J, Barthelaix A, Bayle C,
Beauchet O, Belin C, Belkacem S, Salem DB, Bennys K, Bera G, Berger E, Berger
MG, Bergouin E, Bertin-Hugault F, Bertrand G, Bertrand FX, Beze C, Boilet V,
Bombois S, Bonafé A, Boudali Y, Bouhladour H, Boully C, Bourdel-Marchasson I,
Bouteloup V, Boutet C, Bracard S, Brangier A, Brillet PY, Caillard L, Calvas F,
Camus A, Camus V, Canaple S, Carpentier A, Cassagnaud P, Cattin F, Chamard L,
Chanalet S, Chastan M, Chauvelier S, Chauvire V, Cheriet S, Clotagatide A,
Cognat E, Cohen L, Constans JM, Coste MH, Cottier JP, Cotton F, Couret I,
Couturier OF, Cowppli-Bony P, Cressot V, Crétin B, Danaila K, Darcourt J,
Dartigues JF, Dascalita AM, David R, De Petigny X, De Verbizier-Lonjon D,
Decousus M, Defouilloy I, Delmaire C, Delrieu J, Demuyinck C, Deramecourt V,
Deramond H, Desmidt T, Desruet MD, Detour J, Devendeville A, Didic M, Doireau M,
Santos AD, Douillet P, Boisgueheneuc FD, Dubail D, Ducroq-Ducastaing L,
Dumurgier J, Dupuy D, Duron E, Dygai-Cochet I, Eder V, Epelbaum S,
Etcharry-Bouyx F, Fagret D, Faisant C, Farid K, Fédérico D, Felician O,
Fernandez P, Fosse P, Foubert-Samier A, Franck I, Galitzky M, Gallazzini-Crepin
C, Gantchev R, Garbarg-Chenon L, Gautier G, Gerardin E, Gervais C, Getenet JC,
Girard N, Giraud F, Girtanner C, Gissot V, Grangeon C, Grucker D, Guedj E,
Gueriot C, Guilhermet Y, Guillevin R, Haffen S, Hannequin D, Harston S, Hitzel
A, Hommet C, Hossein-Foucher C, Hubele F, Jacquin-Piques A, Jean B, Jenn J, Joly
L, Jonveaux T, Julian A, Kas A, Kearney-Schwartz A, Keles A, Kelly A, Keromnes
N, Koric L, Krainik A, Kremer S, Labourée F, Lacoeuille F, Lala F, Lamy C,
Laplanche JL, Launay C, Lehericy S, Lehmann S, Lenoir H, Levy M, Libercier S,
Mackowiak-Cordoliani MA, Magnin E, Makaroff Z, Marantidou A, Marcet I, Marelli
C, Marilier S, Martin I, Martinaud O, Martin-Hunyadi C, Medjoul A, Merlet I,
Mestas D, Meyer ME, Michel JM, Michon A, Migeon-Duballet I, Mondon K, Morgat C,
Moullart V, Moussard C, Mouton A, Namer IJ, Niewiadomski G, Nivaggioni G, Noblet
M, Nonent M, Nourhashemi F, Oesterle H, Orvoen G, Ousset PJ, Pallardy A, Paquet
C, Pare PY, Pasco A, Payoux P, Pays C, Pellegrin I, Perdrisot R, Perin B,
Perret-Guillaume C, Petyt G, Philippi N, Pinganaud G, Plichart M, Pop G, Puel M,
Queneau M, Querellou S, Quillard-Muraine M, Quipourt V, Rachez C, Razzouk-Cadet
M, Rigaud AS, Robin-Ismer H, Rodallec M, Rolland Y, Rollin-Sillaire A, Rouaud O,
Roubaud C, Rouch I, Roux J, Sacco G, Salaun PY, Salmon F, Sanchez A,
Santiago-Ribeiro MJ, Sarciron A, Sastre-Hengan N, Sauvée M, Scheiber C,
Schneider AM, Semah F, Serra A, Seux ML, Sordet-Guépet H, Soto ME, Tafani M,
Tanguy JY, Taroux M, Teichmann M, Terrat C, Thabet J, Thalamas C,
Thomas-Anterion C, Troussière AC, Ursu R, Vera P, Vercelletto M, Vercruysse O,
Verger A, Viau P, Videau MN, Voisin T, Wagemann N, Waissi-Sediq A, Xie J, Yeni
N, Zanca M, Zinszner J.
Author information:
(1)University of Bordeaux, Inserm, Bordeaux Population Health Research Center,
UMR 1219, CIC1401-EC, Bordeaux, France.
(2)University of Bordeaux, CNRS UMR 5293, Institut des Maladies
Neurodégénératives, Centre Mémoire de Ressources et de Recherches, Pôle de
Neurosciences Cliniques, CHU de Bordeaux, Bordeaux, France.
(3)Pole de sante publique Centre Hospitalier Universitaire (CHU) de Bordeaux,
Bordeaux, France.
(4)CATI multicentre imaging platform, US52-UAR2031, CEA, ICM, SU, CNRS, INSERM,
APHP, Gif-sur-Yvette, France.
(5)IM2A AP-HP INSERM UMR-S975 Groupe Hospitalier Pitié-Salpêtrière Institut de
la Mémoire et de la Maladie d’Alzheimer Institut du Cerveau et de la Moelle
épinière Sorbonne Université Paris, Paris, France.
(6)ICube laboratory, Pôle de Gériatrie, Université de Strasbourg, CNRS, UMR
7357, Fédération de Médecine Translationnelle de Strasbourg, Centre Mémoire de
Ressources et de Recherches, Strasbourg, France.
(7)Université de Paris Cité, Centre de Neurologie Cognitive GHU APHP Nord
Hôpital Lariboisière, INSERMU1144, Paris, France.
(8)Department of Old Age Psychiatry, Nice University Hospital, Nice, France.
(9)Service de Neurologie Hôpital Saint-Louis AP-HP, Paris, France.
(10)Centre Mémoire de Ressources et de Recherche de Lorraine, Service de
Neurologie CHRU Nancy, Laboratoire Lorrain de Psychologie et de Neurosciences de
la dynamique des comportements 2LPN EA 7489 Université de Lorraine, Nancy,
France.
(11)Service de Neurologie CHU La Milétrie Centre Mémoire de Ressources et de
Recherche, Poitiers, France.
(12)Centre d’Investigation Clinique CIC1402, Poitiers, France.
(13)Department of Neurology, Toulouse University Hospital, Toulouse, France.
(14)Toulouse NeuroImaging Center, Universite de Toulouse, Inserm, UPS, Toulouse,
France.
(15)Université Paris-Saclay, CEA, CNRS, Neurospin, UMR 9027, Gif-sur-Yvette,
France.
INTRODUCTION: This study aims to examine whether physical activity moderates the
association between biomarkers of brain pathologies and dementia risk.
METHODS: From the Memento cohort, we analyzed 1044 patients with mild cognitive
impairment, aged 60 and older. Self-reported physical activity was assessed
using the International Physical Activity Questionnaire. Biomarkers of brain
pathologies comprised medial temporal lobe atrophy (MTA), white matter lesions,
and plasma amyloid beta (Aβ)42/40 and phosphorylated tau181. Association between
physical activity and risk of developing dementia over 5 years of follow-up, and
interactions with biomarkers of brain pathologies were tested.
RESULTS: Physical activity moderated the association between MTA and plasma
Aβ42/40 level and increased dementia risk. Compared to participants with low
physical activity, associations of both MTA and plasma Aβ42/40 on dementia risk
were attenuated in participants with high physical activity.
DISCUSSION: Although reverse causality cannot be excluded, this work suggests
that physical activity may contribute to cognitive reserve.
HIGHLIGHTS: Physical activity is an interesting modifiable target for dementia
prevention. Physical activity may moderate the impact of brain pathology on
dementia risk. Medial temporal lobe atrophy and plasma amyloid beta 42/40 ratio
were associated with increased dementia risk especially in those with low level
of physical activity.
© 2023 The Authors. Alzheimer’s & Dementia published by Wiley Periodicals LLC on
behalf of Alzheimer’s Association.
DOI: 10.1002/alz.13360
PMID: 37422285