Meta-analysis of brain volume changes in obsessive-compulsive disorder.
Biological Psychiatry. 2009-01-01; 65(1): 75-83
DOI: 10.1016/j.biopsych.2008.06.019
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1. Biol Psychiatry. 2009 Jan 1;65(1):75-83. doi: 10.1016/j.biopsych.2008.06.019.
Epub 2008 Aug 21.
Meta-analysis of brain volume changes in obsessive-compulsive disorder.
Rotge JY(1), Guehl D, Dilharreguy B, Tignol J, Bioulac B, Allard M, Burbaud P,
Aouizerate B.
Author information:
(1)Laboratoire Mouvement Adaptation Cognition, CNRS UMR 5227, Université
Bordeaux and Service Universitaire de Psychiatrie, Centre Hospitalier Charles
Perrens, Bordeaux, France.
BACKGROUND: Many neuroimaging studies exploring the volumes of brain structures
in obsessive-compulsive disorder (OCD) have been published in the past 2
decades. In this study, we attempted to provide a complete overview of
structural alterations in OCD by meta-analyzing magnetic resonance imaging (MRI)
data.
METHODS: We conducted a systematic search of MRI studies that reported
volumetric measurements in both OCD patients and healthy subjects. Data were
entered into the meta-analysis through calculation of the standardized mean
differences (SMDs) between the volumes of cerebral regions in OCD patients and
the corresponding volumes in control subjects. We then performed a
meta-regression to explore the influence of clinical covariates on effect sizes.
RESULTS: Although no volumetric differences were found for the whole brain,
intracranial region, gray matter, or prefrontal cortex, OCD patients did show a
reduced volume of the left anterior cingulate cortex (ACC) and the left and
right orbitofrontal cortex (OFC). No significant volumetric differences within
the basal ganglia were observed, although the left and right thalamic volumes
were significantly increased in OCD patients. The severity of obsessive or
compulsive symptoms correlated significantly with the effect sizes for the left
and right thalamus.
CONCLUSIONS: Our findings indicate volumetric differences between OCD patients
and control subjects in the cortical and thalamic regions, suggesting that
structural alteration of the thalamocortical pathways may contribute to the
functional disruptions of frontosubcortical circuits observed in OCD.
DOI: 10.1016/j.biopsych.2008.06.019
PMID: 18718575 [Indexed for MEDLINE]