Longitudinal effects of maternal depressive and anxious symptomatology on child hair cortisol and cortisone from pregnancy to 5-years: The EDEN mother-child cohort
Psychoneuroendocrinology. 2024-04-01; 162: 106957
DOI: 10.1016/j.psyneuen.2024.106957
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1. Psychoneuroendocrinology. 2024 Apr;162:106957. doi:
10.1016/j.psyneuen.2024.106957. Epub 2024 Jan 11.
Longitudinal effects of maternal depressive and anxious symptomatology on child
hair cortisol and cortisone from pregnancy to 5-years: The EDEN mother-child
cohort.
Downes N(1), Kallas KA(2), Moirangthem S(2), Maguet C(2), Marr K(2), Tafflet
M(3), Kirschbaum C(4), Heude B(3), Koehl M(5), Waerden JV(2).
Author information:
(1)Sorbonne Université, INSERM, Institut Pierre Louis d’Epidémiologie et de
Santé Publique (IPLESP), Equipe de Recherche en Epidémiologie Sociale (ERES),
75012 Paris, France. Electronic address: .
(2)Sorbonne Université, INSERM, Institut Pierre Louis d’Epidémiologie et de
Santé Publique (IPLESP), Equipe de Recherche en Epidémiologie Sociale (ERES),
75012 Paris, France.
(3)Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE,
Center for Research in Epidemiology and StatisticS (CRESS), 75004 Paris, France.
(4)Faculty of Psychology, Institute of Biopsychology, Technische Universität
Dresden, 01062 Dresden, Germany.
(5)Univ. Bordeaux, INSERM, Neurocentre Magendie, U1215, Neurogenesis and
Pathophysiology group, 3300 Bordeaux, France.
Exposure to maternal depressive and anxious symptomatology in utero and after
birth can affect child outcomes. One proposed mechanism is through changes in
child stress hormone levels, however current studies present inconsistent
findings, and further research is needed to better understand the impact of
maternal mental health on child stress response. This study aims to add to the
limited literature by analysing longitudinal data ranging from 24 weeks
amenorrhea to 5 years postpartum among 281 mother-child pairs from the French
EDEN mother-child birth cohort. Hair cortisol and cortisone data were collected
from children at four time points: birth, 1, 3, and 5 years. Mothers reported
depressive symptomatology via the Center for Epidemiologic Studies Depression
Scale (CES-D) (at 24-weeks amenorrhea, 3-, and 5-year follow-up), and the
Edinburgh Postnatal Depression Scale (EPDS) (at 4, 8 and 12 months postpartum).
Prenatal anxiety symptomatology was measured via the State Anxiety Inventory
(STAI) at 24 weeks amenorrhea. Group-based trajectory modelling indicated a
1-cluster classification of longitudinal child hair cortisol, cortisone and
cortisol-to-cortisone ratio, as analyses did not reveal a classification by
subgroups representing different child profiles. After inverse probability
weighting, small effects showed prenatal depressive symptomatology was
significantly associated to higher levels of child hair cortisone at one year.
Prenatal anxiety symptomatology was significantly linked to higher levels of
child cortisol measured at birth and cortisone at birth and at 1 year.
Postpartum depressive symptomatology at 8 months was related to higher levels of
cortisone among 3-year-olds. These effects were not moderated by child sex or
maternal socio-economic status. Further research is needed to understand why
there are associations at some time points and not others to determine any
potential buffering factors.
Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.
DOI: 10.1016/j.psyneuen.2024.106957
PMID: 38232529 [Indexed for MEDLINE]
Conflict of interest statement: Declaration of Competing Interest The authors
declare that they have no competing interests. Conflict of interest We have no
conflicts of interest to disclose.