Lateral membrane waves constitute a universal dynamic pattern of motile cells.
Phys. Rev. Lett.. 2006-07-20; 97(3):
DOI: 10.1103/physrevlett.97.038102
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1. Phys Rev Lett. 2006 Jul 21;97(3):038102. Epub 2006 Jul 20.
Lateral membrane waves constitute a universal dynamic pattern of motile cells.
Döbereiner HG(1), Dubin-Thaler BJ, Hofman JM, Xenias HS, Sims TN, Giannone G,
Dustin ML, Wiggins CH, Sheetz MP.
Author information:
(1)Department of Biological Sciences, Columbia University, New York, New York
10027, USA.
We have monitored active movements of the cell circumference on specifically
coated substrates for a variety of cells including mouse embryonic fibroblasts
and T cells, as well as wing disk cells from fruit flies. Despite having
different functions and being from multiple phyla, these cell types share a
common spatiotemporal pattern in their normal membrane velocity; we show that
protrusion and retraction events are organized in lateral waves along the cell
membrane. These wave patterns indicate both spatial and temporal long-range
periodic correlations of the actomyosin gel.
DOI: 10.1103/PhysRevLett.97.038102
PMID: 16907546 [Indexed for MEDLINE]