Dissecting the cannabinergic control of behavior: The where matters.
BioEssays. 2015-08-11; 37(11): 1215-1225
DOI: 10.1002/bies.201500046
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1. Bioessays. 2015 Nov;37(11):1215-25. doi: 10.1002/bies.201500046. Epub 2015 Aug
11.
Dissecting the cannabinergic control of behavior: The where matters.
Busquets-Garcia A(1), Desprez T(1), Metna-Laurent M(1), Bellocchio L(1),
Marsicano G(1), Soria-Gomez E(1).
Author information:
(1)Group « Endocannabinoids and Neuroadaptation, » NeuroCentre Magendie, INSERM
U862, University of Bordeaux, Bordeaux, France.
The endocannabinoid system is the target of the main psychoactive component of
the plant Cannabis sativa, the Δ(9)-tetrahydrocannabinol (THC). This system is
composed by the cannabinoid receptors, the endogenous ligands, and the enzymes
involved in their metabolic processes, which works both centrally and
peripherally to regulate a plethora of physiological functions. This review aims
at explaining how the site-specific actions of the endocannabinoid system impact
on memory and feeding behavior through the cannabinoid receptors 1 (CB1 R).
Centrally, CB1 R is widely distributed in many brain regions, different cell
types (e.g. neuronal or glial cells) and intracellular compartments (e.g.
mitochondria). Interestingly, cellular and molecular effects are differentially
mediated by CB1 R according to their cell-type localization (e.g. glutamatergic
or GABAergic neurons). Thus, understanding the cellular and subcellular function
of CB1 R will provide new insights and aid the design of new compounds in
cannabinoid-based medicine. Also watch the Video Abstract.
© 2015 WILEY Periodicals, Inc.