Dietary fish hydrolysate supplementation containing n-3 LC-PUFAs and peptides prevents short-term memory and stress response deficits in aged mice
Brain, Behavior, and Immunity. 2020-09-01; :
DOI: 10.1016/j.bbi.2020.09.022
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1. Brain Behav Immun. 2020 Sep 23. pii: S0889-1591(20)30743-1. doi:
10.1016/j.bbi.2020.09.022. [Epub ahead of print]
Dietary fish hydrolysate supplementation containing n-3 LC-PUFAs and peptides
prevents short-term memory and stress response deficits in aged mice.
Chataigner M(1), Mortessagne P(2), Lucas C(3), Pallet V(2), Layé S(2),
Mehaignerie A(4), Bouvret E(4), Dinel AL(5), Joffre C(6).
Author information:
(1)Université de Bordeaux, INRAE, Bordeaux INP, NutriNeuro, 146 rue Léo Saignat,
33076 Bordeaux, France; Abyss Ingredients, 56850 Caudan, France.
(2)Université de Bordeaux, INRAE, Bordeaux INP, NutriNeuro, 146 rue Léo Saignat,
33076 Bordeaux, France.
(3)NutriBrain Research and Technology Transfer, NutriNeuro, 146 rue Léo Saignat,
33076 Bordeaux, France.
(4)Abyss Ingredients, 56850 Caudan, France.
(5)Université de Bordeaux, INRAE, Bordeaux INP, NutriNeuro, 146 rue Léo Saignat,
33076 Bordeaux, France; NutriBrain Research and Technology Transfer, NutriNeuro,
146 rue Léo Saignat, 33076 Bordeaux, France.
(6)Université de Bordeaux, INRAE, Bordeaux INP, NutriNeuro, 146 rue Léo Saignat,
33076 Bordeaux, France. Electronic address: .
Brain aging is characterized by a decline in cognitive functions, which can lead
to the development of neurodegenerative pathologies. Age-related spatial learning
and memory deficits are associated with a chronic low-grade inflammation. Anxiety
disorders and stress response alterations, occurring for a part of the elderly,
have also been linked to an increased neuroinflammation and thus, an accelerated
cognitive decline. Nutrition is an innovative strategy to prevent age-related
cognitive impairments. Among the nutrients, n-3 long chain polyunsaturated fatty
acids (LC-PUFAs) and low molecular weight peptides from proteins, especially
those from marine resources, are good candidates for their immunomodulatory,
anxiolytic and neuroprotective properties. The aim of this study is to determine
the combined effect of n-3 LC-PUFAs and low molecular weight peptides on
cognitive functions, and their mechanism of action. We are the first to show that
a dietary supplementation with a fish hydrolysate containing n-3 LC-PUFAs and low
molecular weight peptides prevented the age-related spatial short-term memory
deficits and modulated navigation strategies adopted during spatial learning. In
addition, the fish hydrolysate displayed anxiolytic activities with the reduction
of anxiety-like behaviour in aged mice, restored the plasmatic corticosterone
levels similar to adult animals following an acute stress and modulated the
hypothalamic stress response. These effects on behaviour can be explained by the
immunomodulatory and neuroprotective properties of the fish hydrolysate that
limited microgliosis in vivo, decreased LPS-induced expression of
pro-inflammatory cytokines and increased the expression of growth factors such as
BDNF and NGF in vitro. Thus, n-3 LC-PUFAs and low molecular weight peptides
contained in the fish hydrolysate can play an important role in the limitation of
neuroinflammation and stress response alterations during aging and represent a
potential strategy for the prevention of age-related cognitive decline.
Copyright © 2020 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.bbi.2020.09.022
PMID: 32976934
Conflict of interest statement: Declaration of Competing Interest The authors
declare that they have no known competing financial interests or personal
relationships that could have appeared to influence the work reported in this
paper.