Diabetes and associated cognitive disorders: Role of the Hypothalamic-Pituitary Adrenal axis
Metabolism Open. 2022-09-01; 15: 100202
DOI: 10.1016/j.metop.2022.100202
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Marissal-Arvy N(1), Moisan MP(2).
Author information:
(1)INRAE, Laboratoire de Nutrition et Neurobiologie Intégrée, UMR 1286, UFR de Pharmacie, 146 Rue Léo Saignat, 33076, Bordeaux Cedex, France.
(2)University of Bordeaux, Nutrition et Neurobiologie Intégrée, UMR 1286, 33000, Bordeaux, France.
Both diabetes types, types 1 and 2, are associated with cognitive impairments. Each period of life is concerned, and this is an increasing public health problem. Animal models have been developed to investigate the biological actors involved in such impairments. Many levels of the brain function (structure, volume, neurogenesis, neurotransmission, behavior) are involved. In this review, we detailed the part potentially played by the Hypothalamic-Pituitary Adrenal axis in these dysfunctions. Notably, regulating glucocorticoid levels, their
receptors and their bioavailability appear to be relevant for future research studies, and treatment development.
© 2022 Institut National de la Recherche pour l’Agriculture, l’alimentation et l’environnement.