Cord Serum Cytokines at Birth and Children’s Anxiety-Depression Trajectories From 3 to 8 Years: The EDEN Mother-Child Cohort.
Biological Psychiatry. 2021-03-01; 89(6): 541-549
DOI: 10.1016/j.biopsych.2020.10.009
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1. Biol Psychiatry. 2021 Mar 15;89(6):541-549. doi:
10.1016/j.biopsych.2020.10.009. Epub 2020 Oct 24.
Cord Serum Cytokines at Birth and Children’s Anxiety-Depression Trajectories
From 3 to 8 Years: The EDEN Mother-Child Cohort.
Galera C(1), Barbosa S(2), Collet O(3), Khalfallah O(2), Aouizerate B(4),
Sutter-Dalley AL(5), Koehl M(6), Capuron L(7), Van der Waerden J(8), Melchior
M(8), Côté S(9), Heude B(10), Glaichenhaus N(2), Davidovic L(2); EDEN
Mother–Child Cohort Study Group.
Author information:
(1)Departments of Public Health and Neurocampus, University of Bordeaux,
Bordeaux, France; Institut National de la Santé et de la Recherche Médicale,
Bordeaux Population Health Center, Bordeaux, France; Centre Hospitalier Perrens,
Bordeaux, France; Research Unit on Children’s Psychosocial Maladjustment,
Montreal, Quebec, Canada. Electronic address: .
(2)Université Côte d’Azur, Nice, France; Centre National de la Recherche
Scientifique, Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne,
France.
(3)Departments of Public Health and Neurocampus, University of Bordeaux,
Bordeaux, France; Research Unit on Children’s Psychosocial Maladjustment,
Montreal, Quebec, Canada.
(4)Departments of Public Health and Neurocampus, University of Bordeaux,
Bordeaux, France; Centre Hospitalier Perrens, Bordeaux, France; Bordeaux INP,
NutriNeuro UMR 1286, Bordeaux, France.
(5)Institut National de la Santé et de la Recherche Médicale, Bordeaux
Population Health Center, Bordeaux, France; Centre Hospitalier Perrens,
Bordeaux, France.
(6)Departments of Public Health and Neurocampus, University of Bordeaux,
Bordeaux, France; Institut national de recherche pour l’agriculture,
l’alimentation et l’environnement, Neurocentre Magendie U1215, and Institut
National de la Santé et de la Recherche Médicale, Bordeaux, France.
(7)Departments of Public Health and Neurocampus, University of Bordeaux,
Bordeaux, France; Bordeaux INP, NutriNeuro UMR 1286, Bordeaux, France.
(8)Institut Pierre Louis d’Epidémiologie et de Santé Publique, Sorbonne
Université, Paris, France.
(9)Departments of Public Health and Neurocampus, University of Bordeaux,
Bordeaux, France; Institut National de la Santé et de la Recherche Médicale,
Bordeaux Population Health Center, Bordeaux, France; Research Unit on Children’s
Psychosocial Maladjustment, Montreal, Quebec, Canada; Department of Social and
Preventive Medicine, University of Montreal, Montreal, Quebec, Canada.
(10)Institut National de la Santé et de la Recherche Médicale, INSERM, UMR1153
Epidemiology and Biostatistics Sorbonne Paris Cité Center, ORCHAD Team, Paris,
France; Institut National de la Santé et de la Recherche Médicale, Paris,
France; Paris University, Paris, France.
Comment in
Biol Psychiatry. 2021 Mar 15;89(6):534-535. doi:
10.1016/j.biopsych.2020.12.019.
BACKGROUND: Recent research suggests that immune dysregulation in pregnancy
could be a risk factor for anxiety and depression symptoms in offspring. Whereas
animal studies have demonstrated the importance of the link between perinatal
cytokines and abnormal behaviors in offspring, human epidemiological studies in
this area remain limited. The objectives of the study were to describe the
network of cord serum cytokines at birth and test whether they are associated
with subsequent anxiety and depression symptom trajectories in offspring.
METHODS: We used data and biological samples from 871 mother-child pairs
followed up from pregnancy to 8 years of age and participating in the French
mother-child cohort EDEN (a study on the pre- and early postnatal determinants
of child health and development). Cord serum cytokines were measured at birth.
Children’s symptoms of anxiety and depression were assessed with the emotional
difficulties subscore of the Strength and Difficulties Questionnaire at ages 3,
5, and 8 years, from which trajectories of anxiety-depression symptoms were
derived.
RESULTS: Results showed a significant association between cord serum
interleukin-7 at birth and the trajectories of children’s anxiety-depression
symptoms between ages 3 to 8 years (adjusted odds ratio, 0.73; 95% confidence
interval, 0.57-0.93). The associations considered relevant confounders,
including prenatal maternal depressive symptoms.
CONCLUSIONS: Early immune changes may contribute to subsequent anxiety and
depression symptoms in childhood. Beyond the understanding of mechanisms
underlying the occurrence of emotional difficulties in children, our findings
open avenues for future research in human and animals.
Copyright © 2020 Society of Biological Psychiatry. Published by Elsevier Inc.
All rights reserved.
DOI: 10.1016/j.biopsych.2020.10.009
PMID: 33349450 [Indexed for MEDLINE]