Clinical and pharmacological correlates of caffeine consumption in subjects with schizophrenia – Data from the FACE-SZ cohort.
Journal of Psychiatric Research. 2023-05-01; 161: 206-212
DOI: 10.1016/j.jpsychires.2023.03.017
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1. J Psychiatr Res. 2023 May;161:206-212. doi: 10.1016/j.jpsychires.2023.03.017.
Epub 2023 Mar 13.
Clinical and pharmacological correlates of caffeine consumption in subjects with
schizophrenia – Data from the FACE-SZ cohort.
Szoke A(1), Richard JR(2), Fond G(3), Misdrahi D(4), Lajnef M(2), Aouizerate
B(5), Boyer L(3), Berna F(6), Capdevielle D(7), André M(7), Chereau I(8),
Clauss-Kobayashi J(6), Coulon N(9), Dubertret C(10), Leignier S(9), Llorca
PM(8), Mallet J(10), Passerieux C(11), Rey R(12), Schorr B(6), Urbach M(11),
Leboyer M(13), Pignon B(13), Schürhoff F(13); FACE-SZ (FondaMental Academic
Centers of Expertise for Schizophrenia) group.
Collaborators: Andre M, Andrieu-Haller C, Aouizerate B, Berna F, Blanc O,
Bourguignon E, Capdevielle D, Chereau-Boudet I, Clauss-Kobayashi J, Coulon N,
Dassing R, Dorey JM, Dubertret C, Esselin A, Fond G, Gabayet F, Jarroir M,
Lacelle D, Leboyer M, Leignier S, Llorca PM, Mallet J, Metairie E, Michel T,
Misdrahi D, Passerieux C, Petrucci J, Pignon B, Peri P, Portalier C, Rey R,
Roman C, Schorr B, Schürhoff F, Szoke A, Tessier A, Urbach M, Wachiche G,
Zinetti-Bertschy A.
Author information:
(1)Univ Paris Est Creteil, INSERM, IMRB, AP-HP, Hôpitaux Universitaires « H.
Mondor », DMU IMPACT, Fondation Fondamental, F-94010, Creteil, France.
Electronic address: .
(2)Fondation FondaMental, Créteil, France; INSERM, U955, IMRB, Translational
Neuropsychiatry Lab, Créteil, France.
(3)Fondation FondaMental, Créteil, France; Faculté de Médecine-Secteur Timone,
EA 3279: CEReSS-Centre d’Etude et de Recherche sur les Services de Santé et la
Qualité de vie, Aix-Marseille University, 27 Boulevard Jean Moulin, 13005,
Marseille, France.
(4)Fondation FondaMental, Créteil, France; Centre Hospitalier Charles Perrens,
Université de Bordeaux, 33076, Bordeaux, France; CNRS UMR 5287-INCIA, Pessac,
France.
(5)Fondation FondaMental, Créteil, France; Centre Hospitalier Charles Perrens,
Université de Bordeaux, 33076, Bordeaux, France; INRA, NutriNeuro, University of
Bordeaux, U1286, 33076, Bordeaux, France.
(6)Fondation FondaMental, Créteil, France; INSERM U1114, Fédération de Médecine
Translationnelle de Strasbourg, Hôpitaux Universitaires de Strasbourg,
Université de Strasbourg, Strasbourg, France.
(7)Fondation FondaMental, Créteil, France; Service Universitaire de Psychiatrie
Adulte, Hôpital la Colombière, CHRU Montpellier, Université Montpellier 1,
Inserm 1061, Montpellier, France.
(8)Fondation FondaMental, Créteil, France; CMP B, CHU, EA 7280, Faculté de
Médecine, Université d’Auvergne, BP 69, 63003, Clermont-Ferrand, France.
(9)Fondation FondaMental, Créteil, France; Centre Référent de Réhabilitation
Psychosociale, CH Alpes Isère, Grenoble, France.
(10)Fondation FondaMental, Créteil, France; Department of Psychiatry, Faculté de
Médecine, AP-HP, Louis Mourier Hospital, Université Paris Diderot, Sorbonne
Paris Cité, Inserm U894, Colombes, France.
(11)Fondation FondaMental, Créteil, France; Centre Hospitalier de Versailles,
Service de psychiatrie et d’addictologie adulte, le Chesnay, EA 4047 HANDIReSP,
UFR des Sciences de la Santé Simone Veil, Université Versailles
Saint-Quentin-en-Yvelines, Versailles, France.
(12)Fondation FondaMental, Créteil, France; INSERM U1028, CNRS UMR5292, Centre
de Recherche en Neurosciences de Lyon, Université Claude Bernard Lyon 1, Equipe
PSYR2, Centre Hospitalier le Vinatier, Pole Est, 95 Bd Pinel, BP 30039, 69678,
Bron, France.
(13)Univ Paris Est Creteil, INSERM, IMRB, AP-HP, Hôpitaux Universitaires « H.
Mondor », DMU IMPACT, Fondation Fondamental, F-94010, Creteil, France.
Caffeine is the most consumed psychoactive substance worldwide. Previous studies
suggested higher caffeine consumption in subjects with schizophrenia spectrum
disorders (SSD) as well as associations with symptoms, medication and medication
side-effects. In a large and well-characterized sample of SSD subjects we
explored the association between caffeine consumption and clinical (psychosis
related, severity, general health) as well as pharmacological (antipsychotic
treatment, sedation potential) variables. Eight hundred four subjects with data
on their caffeine (coffee and tea) consumption successively recruited were
included in this study. After controlling for potential confounders (demographic
variables, smoking) only the negative dimension of psychosis was associated with
the amount of caffeine ingested. Less severe negative symptoms were associated
with higher caffeine consumption. The effect size of this association was small
(partial correlation coefficient = -0.12) but significant.
Copyright © 2023 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.jpsychires.2023.03.017
PMID: 36934602 [Indexed for MEDLINE]
Conflict of interest statement: Declaration of competing interest The authors
have declared that there are no conflicts of interest in relation to the subject
of this study.