Chronic Peripheral Inflammation is Associated With Cognitive Impairment in Schizophrenia: Results From the Multicentric FACE-SZ Dataset.
SCHBUL. 2016-05-03; 42(5): 1290-1302
DOI: 10.1093/schbul/sbw029
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Bulzacka E(1), Boyer L(2), Schürhoff F(3), Godin O(4), Berna F(5), Brunel L(1),
Andrianarisoa M(1), Aouizerate B(6), Capdevielle D(7), Chéreau-Boudet I(3),
Chesnoy-Servanin G(8), Danion JM(5), Dubertret C(9), Dubreucq J(10), Faget
C(11), Gabayet F(10), Le Gloahec T(1), Llorca PM(3), Mallet J(9), Misdrahi
D(12), Rey R(8), Richieri R(11), Passerieux C(13), Roux P(13), Yazbek H(7),
Leboyer M(1), Fond G(14); FACE-SZ (FondaMental Academic Centers of Expertise for
Schizophrenia) Group.
Author information:
(1)Fondation FondaMental, RTRS santé mentale, Créteil, France; INSERM U955,
Translational Psychiatry Team, Créteil, France, Paris Est University, DHU
Pe-PSY, Pôle de Psychiatrie des Hôpitaux Universitaires H Mondor, Créteil,
France;
(2)Fondation FondaMental, RTRS santé mentale, Créteil, France; Pôle psychiatrie
universitaire, CHU Sainte-Marguerite, F-13274 Marseille cedex 09, France;
(3)Fondation FondaMental, RTRS santé mentale, Créteil, France; CMP B, CHU, EA
7280 Faculté de Médecine, Université d’Auvergne, BP 69 63003 Clermont-Ferrand
Cedex 1, France;
(4)Fondation FondaMental, RTRS santé mentale, Créteil, France; Sorbonne
Universités, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis
d’Epidémiologie et de Santé Publique, F-75013, Paris, France, INSERM, UMR_S
1136, Institut Pierre Louis d’Epidémiologie et de Santé Publique, F-75013,
Paris, France;
(5)Fondation FondaMental, RTRS santé mentale, Créteil, France; Hôpitaux
Universitaires de Strasbourg, Université de Strasbourg, INSERM U1114, Fédération
de Médecine Translationnelle de Strasbourg, Strasbourg, France;
(6)Fondation FondaMental, RTRS santé mentale, Créteil, France; Centre
Hospitalier Charles Perrens, Université de Bordeaux, F-33076 Bordeaux, France;
Inserm, Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, U862,
F-33000 Bordeaux, France;
(7)Fondation FondaMental, RTRS santé mentale, Créteil, France; Service
Universitaire de Psychiatrie Adulte, Hôpital la Colombière, CHRU Montpellier,
Université Montpellier 1, Inserm 1061, Montpellier, France;
(8)Fondation FondaMental, RTRS santé mentale, Créteil, France; Université Claude
Bernard Lyon 1/Centre Hospitalier Le Vinatier Pole Est BP 300 39- 95 bd
Pinel-69678 BRON Cedex, France;
(9)Fondation FondaMental, RTRS santé mentale, Créteil, France; AP-HP, Department
of Psychiatry, Louis Mourier Hospital, Colombes, Inserm U894, Université Paris
Diderot, Sorbonne Paris Cité, Faculté de médecine, France;
(10)Fondation FondaMental, RTRS santé mentale, Créteil, France; Centre Référent
de Réhabilitation Psychosociale, CH Alpes Isère, Grenoble, France;
(11)Fondation FondaMental, RTRS santé mentale, Créteil, France; Assistance
Publique des Hôpitaux de Marseille (AP-HM), pôle universitaire de psychiatrie,
Marseille, France;
(12)Fondation FondaMental, RTRS santé mentale, Créteil, France; Centre
Hospitalier Charles Perrens, Université de Bordeaux, F-33076 Bordeaux, France;
CNRS UMR 5287 – Institut de Neurosciences cognitives et intégratives d’Aquitaine
(INCIA), Bordeaux, France;
(13)Fondation FondaMental, RTRS santé mentale, Créteil, France; Service de
psychiatrie d’adulte, Centre Hospitalier de Versailles, UFR des Sciences de la
Santé Simone Veil, Université Versailles Saint-Quentin en Yvelines, Versailles,
France.
(14)Fondation FondaMental, RTRS santé mentale, Créteil, France; INSERM U955,
Translational Psychiatry Team, Créteil, France, Paris Est University, DHU
Pe-PSY, Pôle de Psychiatrie des Hôpitaux Universitaires H Mondor, Créteil,
France; .
OBJECTIVES: Inflammation, measured by abnormal blood C-reactive protein (CRP)
level, has been described in schizophrenia (SZ), being inconsistently related to
impaired cognitive functions. The aim of the present study is to investigate
cognitive impairment associated with abnormal CRP levels in a large
multi-centric sample of community-dwelling SZ patients, using a comprehensive
neuropsychological battery.
METHOD: Three hundred sixty-nine community-dwelling stable SZ subjects (76.2%
men, mean age 32.7 y) were included and tested with a comprehensive battery of
neuropsychological tests. Abnormal CRP level was defined as >3mg/L.
RESULTS: Multiple factor analysis revealed that abnormal CRP levels, found in
104 patients (28.2%), were associated with impaired General Intellectual Ability
and Abstract Reasoning (aOR = 0.56, 95% CI 0.35-0.90, P = .014), independently
of age, sex, education level, psychotic symptomatology, treatments, and
addiction comorbidities. Abnormal CRP levels were also associated with the
decline of all components of working memory (respectively effect size [ES] =
0.25, P = .033; ES = 0.27, P = .04; ES = 0.33, P = .006; and ES = 0.38, P =
.004) and a wide range of other impaired cognitive functions, including memory
(ES = 0.26, P = .026), learning abilities (ES = 0.28, P = .035), semantic memory
(ES = 0.26, P = .026), mental flexibility (ES = 0.26, P = .044), visual
attention (ES = 0.23, P = .004) and speed of processing (ES = 0.23, P = .043).
CONCLUSION: Our results suggest that abnormal CRP level is associated with
cognitive impairment in SZ. Evaluating the effectiveness of neuroprotective
anti-inflammatory strategies is needed in order to prevent cognitive impairment
in SZ.
© The Author 2016. Published by Oxford University Press on behalf of the
Maryland Psychiatric Research Center. All rights reserved. For permissions,
please email: .
DOI: 10.1093/schbul/sbw029
PMCID: PMC4988740
PMID: 27143795 [Indexed for MEDLINE]