Childhood maltreatment and clinical severity of treatment-resistant depression in a French cohort of outpatients (FACE-DR): One-year follow-up.
Depression and Anxiety. 2020-01-30; 37(4): 365-374
DOI: 10.1002/da.22997
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1. Depress Anxiety. 2020 Apr;37(4):365-374. doi: 10.1002/da.22997. Epub 2020 Jan
30.
Childhood maltreatment and clinical severity of treatment-resistant depression
in a French cohort of outpatients (FACE-DR): One-year follow-up.
Yrondi A(1)(2), Aouizerate B(1)(3), Bennabi D(1)(4), Richieri R(1)(5), D’Amato
T(1)(6)(7), Bellivier F(1)(8), Bougerol T(1)(9), Horn M(1)(10), Camus V(1)(11),
Courtet P(1)(12), Doumy O(1)(3), Genty JB(1)(13), Holtzmann J(1)(9), Lancon
C(1)(5), Leboyer M(1)(13), Llorca PM(1)(14), Maruani J(1)(8), Moirand
R(1)(6)(7), Molière F(1)(12), Samalin L(1)(14), Schmitt L(1)(2), Stephan
F(1)(15), Turecki G(16), Vaiva G(1)(17), Walter M(1)(15), Petrucci J(1)(13);
FondaMental Advanced Centers of Expertise in Resistant Depression (FACE-DR)
Collaborators; Haffen E(1)(4), El-Hage W(1)(11).
Author information:
(1)Fondation FondaMental, Creteil, France.
(2)Service de Psychiatrie et de Psychologie Médicale de l’adulte, Centre Expert
Dépression Résistante FondaMental, CHU de Toulouse, Hôpital Purpan,ToNIC
Toulouse NeuroImaging Center, Université de Toulouse, INSERM/UPS, Toulouse,
France.
(3)Pôle de Psychiatrie Générale et Universitaire, Centre Expert Dépression
Résistante FondaMental, CH Charles Perrens, Bordeaux, Laboratoire Nutrition et
Neurobiologie intégrée (UMR INRA 1286), Université de Bordeaux, Bordeaux,
France.
(4)Service de Psychiatrie, Centre Expert Dépression Résistante FondaMental,
CIC-1431 INSERM, CHU de Besançon, EA 481 Neurosciences, Université de Bourgogne
Franche Comté, Besançon, France.
(5)Pôle Psychiatrie, Centre Expert Dépression Résistante FondaMental, CHU La
Conception, Marseille, France.
(6)INSERM U1028, CNRS UMR5292, University Lyon 1, Villeurbanne, France.
(7)Lyon Neuroscience Research Center, Psychiatric Disorders: From Resistance to
Response ΨR2 Team, Centre Hospitalier Le Vinatier, Bron, France.
(8)AP-HP, GH Saint-Louis – Lariboisière-Fernand Widal, Pôle Neurosciences Tête
et Cou, INSERM UMRS 1144, University Paris Diderot, Paris, France.
(9)Grenoble Institut Neurosciences, Inserm, U1216, CHU Grenoble Alpes,
Université Grenoble Alpe, Grenoble, France.
(10)Service de Psychiatrie Adulte, Centre Expert Dépression Résistante
FondaMental, Hôpital Fontan 1, CHRU de Lille, Lille, France.
(11)U1253, iBrain, CIC1415, Inserm, CHRU de Tours, Université de Tours, Tours,
France.
(12)Department of Emergency Psychiatry and Acute Care, CHU Montpellier, INSERM
U1061, Montpellier University, Montpellier, France.
(13)Université Paris-Est, UMR_S955, UPEC, Créteil, France Inserm, U955, Equipe
15 Psychiatrie génétique, Créteil, France AP-HP, Hôpital H. Mondor-A. Chenevier,
Pôle de Psychiatrie, Créteil, France Fondation FondaMental, Fondation de
Cooperation Scientifique, Créteil, France.
(14)Department of Psychiatry, CHU Clermont-Ferrand, University of Clermont
Auvergne, Clermont-Ferrand, France.
(15)Service Hospitalo-Universitaire de Psychiatrie Générale et de Réhabilitation
Psycho Sociale 29G01 et 29G02, Centre Expert Depression Résistante FondaMental,
EA 7479, CHRU de Brest, Hôpital de Bohars, Brest, France.
(16)McGill Group for Suicide Studies, Department of Psychiatry, Douglas Mental
Health University Institute, McGill University, Montreal, Quebec, Canada.
(17)Centre National de Ressources et Résilience pour les psychotraumatismes,
Lille, France.
BACKGROUND: Childhood maltreatment is associated with major depressive disorder
(MDD). It not only increases the risk of lifetime MDD, but it also aggravates
its course. Among depressed patients, 20-30% of them experience
treatment-resistance depression (TRD). We aimed to assess the association
between childhood maltreatment, severity of depression in a unipolar TRD sample,
and patient outcomes after one-year of follow-up.
METHODS: Patients were recruited for a prospective cohort from the French
network of TRD expert centers. Depressive symptom severity was assessed with the
Montgomery-Åsberg Depression Rating Scale (MADRS) and the Quick Inventory of
Depressive Symptomatology self-report (QIDS-SR). Childhood maltreatment was
evaluated with the Childhood Trauma Questionnaire (CTQ).
RESULTS: In total, 256 patients filled in the CTQ at baseline between 2012 and
2019. At baseline, the MADRS score was associated with CTQ score (β = .185;
p = .004). QIDS was also associated with CTQ scores (β = .27; p