Behavioral reactivity to novelty during youth as a predictive factor of stress-induced corticosterone secretion in the elderly – A life-span study in rats
Psychoneuroendocrinology. 1996-07-01; 21(5): 441-453
DOI: 10.1016/0306-4530(96)00017-0
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Dellu F(1), Mayo W, Vallée M, Maccari S, Piazza PV, Le Moal M, Simon H.
Author information:
(1)Laboratoire de Psychobiologie des Comportements Adaptatifs, INSERM U.259,
Université de Bordeaux II, France.
Inter- and intra-individual differences in hypothalamo-pituitary adrenal (HPA)
axis activity and behavioral reactivity to novelty between young and old rats
were evidenced in this longitudinal life-span study. Higher responders to
novelty (HR) had a higher corticosterone secretion which showed a quicker
increase with age than did the others (LR); the differences in response to
novelty observed in youth were no longer apparent in the old rats. Response to
novelty in youth is a predictive factor of accelerated aging of the HPA axis.
These early changes, which precede the appearance of the memory deficits, may be
a causal factor. Disappearance of behavioral and endocrinological
inter-individual differences at 21 months highlights the importance of not
restricting aging studies to old subjects.
DOI: 10.1016/0306-4530(96)00017-0
PMID: 8888367 [Indexed for MEDLINE]