Associations of white blood cell and platelet counts with specific depressive symptom dimensions in patients with bipolar disorder: Analysis of data from the FACE-BD cohort.
Brain, Behavior, and Immunity. 2023-02-01; 108: 176-187
DOI: 10.1016/j.bbi.2022.12.002
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1. Brain Behav Immun. 2023 Feb;108:176-187. doi: 10.1016/j.bbi.2022.12.002. Epub
2022 Dec 6.
Associations of white blood cell and platelet counts with specific depressive
symptom dimensions in patients with bipolar disorder: Analysis of data from the
FACE-BD cohort.
Lengvenyte A(1), Strumila R(2), Belzeaux R(3), Aouizerate B(4), Dubertret C(5),
Haffen E(6), Llorca PM(7), Roux P(8), Polosan M(9), Schwan R(10), Walter M(11),
D’Amato T(12), Januel D(13), Leboyer M(14), Bellivier F(15), Etain B(15),
Navickas A(16); FondaMental Advanced Centres of Expertise in Bipolar Disorders
(FACE-BD) Collaborators(17); Olié E(18), Courtet P(18).
Author information:
(1)Department of Emergency Psychiatry and Acute Care, Lapeyronie Hospital CHU
Montpellier, Montpellier, France; IGF, Univ. Montpellier, CNRS, INSERM,
Montpellier, France; Faculty of Medicine, Institute of Clinical Medicine,
Psychiatric Clinic, Vilnius University, Vilnius, Lithuania; Fondation
FondaMental, France. Electronic address: .
(2)Department of Emergency Psychiatry and Acute Care, Lapeyronie Hospital CHU
Montpellier, Montpellier, France; IGF, Univ. Montpellier, CNRS, INSERM,
Montpellier, France; Faculty of Medicine, Institute of Clinical Medicine,
Psychiatric Clinic, Vilnius University, Vilnius, Lithuania.
(3)IGF, Univ. Montpellier, CNRS, INSERM, Montpellier, France; Fondation
FondaMental, France; Pôle de Psychiatrie, Assistance Publique Hôpitaux de
Marseille, Marseille, France; INT-UMR7289, CNRS Aix-Marseille Université,
Marseille, France.
(4)Fondation FondaMental, France; Centre Hospitalier Charles Perrens, Bordeaux,
France; Laboratoire NutriNeuro (UMR INRA 1286), Université de Bordeaux,
Bordeaux, France.
(5)Fondation FondaMental, France; Université Paris Cité, Paris, France; AP-HP,
Groupe Hospitalo-Universitaire AP-HP Nord, DMU ESPRIT, Service de Psychiatrie et
Addictologie, Hôpital Louis Mourier, Colombes, France; Université de Paris,
Inserm UMR1266, Sorbonne Paris Cité, Faculté de Médecine, Paris, France.
(6)Fondation FondaMental, France; Service de Psychiatrie de l’Adulte, CIC-1431
INSERM, CHU de Besançon, Laboratoire de Neurosciences, UFC, UBFC, Besançon,
France.
(7)Fondation FondaMental, France; Centre Hospitalier et Universitaire,
Département de Psychiatrie, Clermont-Ferrand, France; Université d’Auvergne, EA
7280 Clermont-Ferrand, France.
(8)Fondation FondaMental, France; Université Paris-Saclay, UVSQ, CESP UMR1018,
DevPsy-DisAP, Centre Hospitalier de Versailles, Pôle de Psychiatrie et Santé
Mentale, 78157 Le Chesnay, France.
(9)Fondation FondaMental, France; Univ. Grenoble Alpes, Inserm, U1216, CHU
Grenoble Alpes, Grenoble Institut Neurosciences, Grenoble, France.
(10)Fondation FondaMental, France; Université de Lorraine, Centre
Psychothérapique de Nancy, Inserm U1254, Nancy, France.
(11)Fondation FondaMental, France; Service Hospitalo-Universitaire de
Psychiatrie Générale et de Réhabilitation Psycho Sociale 29G01 et 29G02, CHRU de
Brest, Hôpital de Bohars, Brest, France.
(12)Fondation FondaMental, France; University Lyon 1, Villeurbanne, France;
INSERM, U1028, CNRS, UMR5292, Lyon Neuroscience Research Center, Psychiatric
Disorders: From Resistance to Response Team, Lyon, France.
(13)Fondation FondaMental, France; Unité de Recherche Clinique, EPS
Ville-Evrard, 93332 Neuilly-sur-Marne, France.
(14)Fondation FondaMental, France; Univ Paris Est Créteil, INSERM U955, IMRB,
Translational NeuroPsychiatry Laboratory, Créteil, France; AP-HP, Hôpitaux
Universitaires Henri Mondor, Département Médico-Universitaire de Psychiatrie et
d’Addictologie (DMU IMPACT), Fédération Hospitalo-Universitaire de Médecine de
Précision en Psychiatrie (FHU ADAPT), Créteil, France.
(15)Fondation FondaMental, France; Université Paris Cité, Paris, France; AP-HP,
Groupe Hospitalo-Universitaire AP-HP Nord, DMU Neurosciences, Hôpital Fernand
Widal, Département de Psychiatrie et de Médecine Addictologique, Paris, France;
Université Paris Cité, INSERM UMR-S 1144, Optimisation Thérapeutique en
Neuropsychopharmacologie OTeN, Paris, France.
(16)Faculty of Medicine, Institute of Clinical Medicine, Psychiatric Clinic,
Vilnius University, Vilnius, Lithuania.
(17)Fondation FondaMental, France.
(18)Department of Emergency Psychiatry and Acute Care, Lapeyronie Hospital CHU
Montpellier, Montpellier, France; IGF, Univ. Montpellier, CNRS, INSERM,
Montpellier, France; Fondation FondaMental, France.
Evidences suggest that inflammation is increased in a subgroup of patients with
depression. Moreover, increased peripheral inflammatory markers (cells and
proteins) are associated with some, but not all depressive symptoms. On the
other hand, similar studies on bipolar disorders mainly focused on blood
cytokines. Here, we analysed data from a large (N = 3440), well-characterized
cohort of individuals with bipolar disorder using Kendall partial rank
correlation, multivariate linear regression, and network analyses to determine
whether peripheral blood cell counts are associated with depression severity,
its symptoms, and dimensions. Based on the self-reported 16-Item Quick Inventory
of Depressive Symptomatology questionnaire scores, we preselected symptom
dimensions based on literature and data-driven principal component analysis. We
found that the counts of all blood cell types were only marginally associated
with depression severity. Conversely, white blood cell count was significantly
associated with the sickness dimension and its four components (anhedonia,
slowing down, fatigue, and appetite loss). Platelet count was associated with
the insomnia/restlessness dimension and its components (initial, middle, late
insomnia and restlessness). Principal component analyses corroborated these
results. Platelet count was also associated with suicidal ideation. In analyses
stratified by sex, the white blood cell count-sickness dimension association
remained significant only in men, and the platelet count-insomnia/restlessness
dimension association only in women. Without implying causation, these results
suggest that peripheral blood cell counts might be associated with different
depressive symptoms in individuals with bipolar disorder, and that white blood
cells might be implicated in sickness symptoms and platelets in
insomnia/agitation and suicidal ideation.
Copyright © 2022 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.bbi.2022.12.002
PMID: 36494046 [Indexed for MEDLINE]
Conflict of interest statement: Declaration of Competing Interest The authors
declare that they have no known competing financial interests or personal
relationships that could have appeared to influence the work reported in this
paper.