Arkypallidal Cells Send a Stop Signal to Striatum
Neuron. 2016-01-01; 89(2): 308-316
DOI: 10.1016/j.neuron.2015.12.017
![PubMed](https://www.bordeaux-neurocampus.fr/wp-content/uploads/2019/01/logoPubMed.png)
Lire sur PubMed
1. Neuron. 2016 Jan 20;89(2):308-16. doi: 10.1016/j.neuron.2015.12.017.
Arkypallidal Cells Send a Stop Signal to Striatum.
Mallet N(1), Schmidt R, Leventhal D, Chen F, Amer N, Boraud T, Berke JD.
Author information:
(1)Universite de Bordeaux, Institut des Maladies Neurodegeneratives, 33076
Bordeaux, France
Comment in
Neuron. 2016 Jan 20;89(2):237-9.
Mov Disord. 2016 Aug;31(8):1142.
The suppression of inappropriate actions is critical for flexible behavior.
Cortical-basal ganglia networks provide key gating mechanisms for action
suppression, yet the specific roles of neuronal subpopulations are poorly
understood. Here, we examine Arkypallidal (‘‘Arky’’) and Prototypical (‘‘Proto’’)
globus pallidus neurons during a Stop task, which requires abrupt cancellation of
an imminent action. We first establish that Arky neurons can be identified by
their firing properties across the natural sleep/wake cycle. We then show that
Stop responses are earlier and stronger in the Arky compared to the Proto
subpopulation. In contrast to other basal ganglia neurons, pallidal Stop
responses are selective to Stop, rather than Go, cues. Furthermore, the timing of
these Stop responses matches the suppression of developing striatal Go-related
activity. Our results support a two-step model of action suppression:
actions-inpreparation are first paused via a subthalamic-nigral pathway, then
cancelled via Arky GABAergic projections to striatum.
DOI: 10.1016/j.neuron.2015.12.017
PMCID: PMC4871723
PMID: 26777273 [Indexed for MEDLINE]