A sympathetic brake on gut GLP-1 release
Neuron. 2024-03-01; 112(6): 865-867
DOI: 10.1016/j.neuron.2024.02.015
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López-Gambero AJ(1), Jouque V(1), Cota D(2).
Author information:
(1)University of Bordeaux, INSERM, Neurocentre Magendie, U1215, F-33000
Bordeaux, France.
(2)University of Bordeaux, INSERM, Neurocentre Magendie, U1215, F-33000
Bordeaux, France. Electronic address: .
The brain-gut neurocircuitry is proving to be finely involved in a wide range of
physiological functions. In this issue of Neuron, Ren et al.1 show that
adrenergic signaling suppresses postprandial glucagon-like peptide 1 (GLP-1)
secretion. This, in turn, raises circulating glucose levels and impairs brain
glucose uptake and cognitive function.
Copyright © 2024 Elsevier Inc. All rights reserved.
Conflict of interest statement: Declaration of interests The authors declare no
competing interests.