Learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice

1. Behav Brain Funct. 2005 Apr 22;1(1):3.

Learning spatial orientation tasks in the radial-maze and structural variation in
the hippocampus in inbred mice.

Crusio WE(1), Schwegler H.

Author information:
(1)Brudnick Neuropsychiatric Research Institute, Department of Psychiatry,
University of Massachusetts Medical School, 303 Belmont Street, Worcester, MA
01604, USA. .

In the present paper we review a series of experiments showing that heritable
variations in the size of the hippocampal intra- and infrapyramidal mossy fiber
(IIPMF) terminal fields correlate with performance in spatial, but not
non-spatial radial-maze tasks. Experimental manipulation of the size of this
projection by means of early postnatal hyperthyroidism produces the effects
predicted from the correlations obtained with inbred mouse strains. Although the
physiological mechanisms behind these correlations are unknown as yet, several
lines of evidence indicate that these correlations are causal.

DOI: 10.1186/1744-9081-1-3
PMCID: PMC1143776
PMID: 15916698

Auteurs Bordeaux Neurocampus