A common origin of synaptic vesicles undergoing evoked and spontaneous fusion.
Nat Neurosci. 2010-11-21; 13(12): 1451-1453
DOI: 10.1038/nn.2695
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1. Nat Neurosci. 2010 Dec;13(12):1451-3. doi: 10.1038/nn.2695.
A common origin of synaptic vesicles undergoing evoked and spontaneous fusion.
Hua Y(1), Sinha R, Martineau M, Kahms M, Klingauf J.
Author information:
(1)Department of Membrane Biophysics, Max Planck Institute for Biophysical
Chemistry, Göttingen, Germany.
There is a longstanding controversy on the identity of synaptic vesicles
undergoing spontaneous versus evoked release. A recent study, introducing a new
genetic probe, suggested that spontaneous release is driven by a resting pool of
synaptic vesicles refractory to stimulation. We found that cross-depletion of
spontaneously or actively recycling synaptic vesicle pools occurred on
stimulation in rat hippocampal neurons and identified the recycling pool as a
major source of spontaneous release.
DOI: 10.1038/nn.2695
PMID: 21102448 [Indexed for MEDLINE]