L-dopa-induced dyskinesia: beyond an excessive dopamine tone in the striatum.
Sci Rep. 2014-01-16; 4(1):
DOI: 10.1038/srep03730
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1. Sci Rep. 2014 Jan 16;4:3730. doi: 10.1038/srep03730.
L-dopa-induced dyskinesia: beyond an excessive dopamine tone in the striatum.
Porras G(1), De Deurwaerdere P(2), Li Q(3), Marti M(4), Morgenstern R(5), Sohr
R(5), Bezard E(6), Morari M(7), Meissner WG(8).
Author information:
(1)1] Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293,
33000 Bordeaux, France [2] CNRS, Institut des Maladies Neurodégénératives, UMR
5293, 33000 Bordeaux, France [3] Motac neuroscience, Manchester, UK.
(2)1] Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293,
33000 Bordeaux, France [2] CNRS, Institut des Maladies Neurodégénératives, UMR
5293, 33000 Bordeaux, France.
(3)1] Motac neuroscience, Manchester, UK [2] Institute of Laboratory Animal
Sciences, China Academy of Medical Sciences, Beijing, China.
(4)Department of Life Sciences and Biotechnology (SVeB), University of Ferrara,
Ferrara, Italy.
(5)Institute of Pharmacology and Toxicology, Charité Campus Mitte, Humboldt
University, 10117 Berlin, Germany.
(6)1] Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293,
33000 Bordeaux, France [2] CNRS, Institut des Maladies Neurodégénératives, UMR
5293, 33000 Bordeaux, France [3] Motac neuroscience, Manchester, UK [4] Institute
of Laboratory Animal Sciences, China Academy of Medical Sciences, Beijing, China
[5] Service de Neurologie, Centre Expert Parkinson, CHU de Bordeaux, 33076
Bordeaux, France.
(7)Department of Medical Sciences, Section of Pharmacology, University of
Ferrara, Ferrara, Italy.
(8)1] Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293,
33000 Bordeaux, France [2] CNRS, Institut des Maladies Neurodégénératives, UMR
5293, 33000 Bordeaux, France [3] Service de Neurologie, Centre Expert Parkinson,
CHU de Bordeaux, 33076 Bordeaux, France [4] Centre de référence AMS, CHU de
Bordeaux, 33076 Bordeaux, France.
L-dopa remains the mainstay treatment for Parkinson’s disease (PD), although in
later stages, treatment is complicated by L-dopa-induced dyskinesias (LID).
Current evidence links LID to excessive striatal L-dopa-derived dopamine (DA)
release, while the possibility of a direct involvement of L-dopa itself in LID
has been largely ignored. Here we show that L-dopa can alter basal ganglia
activity and produce LID without enhancing striatal DA release in parkinsonian
non-human primates. These data may have therapeutic implications for the
management of advanced PD since they suggest that LID could result from diverse
mechanisms of action of L-dopa.
DOI: 10.1038/srep03730
PMCID: PMC3893648
PMID: 24429495 [Indexed for MEDLINE]