Basal ganglia dysfunction in OCD: subthalamic neuronal activity correlates with symptoms severity and predicts high-frequency stimulation efficacy.
Transl Psychiatry. 2011-05-03; 1(5): e5-e5
DOI: 10.1038/tp.2011.5
Lire sur PubMed
1. Transl Psychiatry. 2011 May 3;1(5):e5. doi: 10.1038/tp.2011.5.
Basal ganglia dysfunction in OCD: subthalamic neuronal activity correlates with
symptoms severity and predicts high-frequency stimulation efficacy.
Welter ML(1), Burbaud P, Fernandez-Vidal S, Bardinet E, Coste J, Piallat B, Borg
M, Besnard S, Sauleau P, Devaux B, Pidoux B, Chaynes P, Tézenas du Montcel S,
Bastian A, Langbour N, Teillant A, Haynes W, Yelnik J, Karachi C, Mallet L;
French Stimulation dans Trouble Obsessionnel Compulsif (STOC) Study Group.
Collaborators: Mallet L, Agid Y, Aouizerate B, Arbus C, Bougerol T, Damier P,
Fontaine D, Houeto JL, Krebs MO, Lemaire JJ, Mallet L, Millet B, Pollak P,
Hourton D, Aprelon S, Jourdain C, Bardinet E, Yelnik J, Burbaud P, Welter ML,
Clair AH, Czernecki C, Vérin M, Tézenas du Montcel S, Madar D, Mallet L,
Pelissolo A, Tezenas du Montcel S, Welter ML, Yelnik J, Mallet L, Pelissolo A,
Agid Y, Cornu P, Navarro S, Welter ML, Hartmann A, Pidoux B, Grabli D, Czernecki
V, Dormont D, Galanaud D, Yelnik J, Bardinet E, Béhar C, Worbe Y, Clair AH,
Moutaud B, Aouizerate B, Burbaud P, Cuny E, Guehl D, Llorca PM, Chéreau I,
Lemaire JJ, Durif F, Derost P, Coste J, Gabrillargues J, Barget M, de Chazeron
I, Bougerol T, Polosan M, Benabid AL, Chabardès S, Seigneuret E, Krack P, Pollak
P, Ardouin C, Le Bas JF, Damier P, Lajat Y, Raoul S, Mattei V, Fontaine D, Borg
M, Paquis P, Michel E, Robert P, Michel E, Papetti F, Baup N, Devaux B, Krebs
MO, Oppenheimer C, Olié JP, Ranoux D, Chayet M, Houeto JL, Jaafari N, Bataille
B, Mesnage V, Gil R, Audouin V, Senon JL, Millet B, Vérin M, Drapier D, Sauleau
P, Drapier S, Arbus C, Lazorthe Y, Chaynes P, Fabre N, Simonetta M, Schmitt L,
Lotterie JA, Camassel C, Best N, Aussilloux JC, Blond S, Feingold J, Sicard D,
Adès J, Cottraux J, Goudemand M.
Author information:
(1)Centre de Recherche de l’Institut du Cerveau et de Moelle épiniere,
Université Pierre et Marie Curie-Paris 6, UMR-S975, Paris, France.
Functional and connectivity changes in corticostriatal systems have been
reported in the brains of patients with obsessive-compulsive disorder (OCD);
however, the relationship between basal ganglia activity and OCD severity has
never been adequately established. We recently showed that deep brain
stimulation of the subthalamic nucleus (STN), a central basal ganglia nucleus,
improves OCD. Here, single-unit subthalamic neuronal activity was analysed in 12
OCD patients, in relation to the severity of obsessions and compulsions and
response to STN stimulation, and compared with that obtained in 12 patients with
Parkinson’s disease (PD). STN neurons in OCD patients had lower discharge
frequency than those in PD patients, with a similar proportion of burst-type
activity (69 vs 67%). Oscillatory activity was present in 46 and 68% of neurons
in OCD and PD patients, respectively, predominantly in the low-frequency band
(1-8 Hz). In OCD patients, the bursty and oscillatory subthalamic neuronal
activity was mainly located in the associative-limbic part. Both OCD severity
and clinical improvement following STN stimulation were related to the STN
neuronal activity. In patients with the most severe OCD, STN neurons exhibited
bursts with shorter duration and interburst interval, but higher intraburst
frequency, and more oscillations in the low-frequency bands. In patients with
best clinical outcome with STN stimulation, STN neurons displayed higher mean
discharge, burst and intraburst frequencies, and lower interburst interval.
These findings are consistent with the hypothesis of a dysfunction in the
associative-limbic subdivision of the basal ganglia circuitry in OCD’s
pathophysiology.
DOI: 10.1038/tp.2011.5
PMCID: PMC3309476
PMID: 22832400 [Indexed for MEDLINE]