Contextual and behavioral influences on uncertainty in obsessive-compulsive disorder.
Cortex. 2015-01-01; 62: 1-10
DOI: 10.1016/j.cortex.2012.12.010
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1. Cortex. 2015 Jan;62:1-10. doi: 10.1016/j.cortex.2012.12.010. Epub 2012 Dec 23.
Contextual and behavioral influences on uncertainty in obsessive-compulsive
disorder.
Rotge JY(1), Langbour N(2), Dilharreguy B(3), Bordessoulles M(4), Guehl D(5),
Bioulac B(5), Martin-Guehl C(6), Jaafari N(7), Aouizerate B(8), Allard M(4),
Burbaud P(5).
Author information:
(1)Institut des Maladies Neurodégénératives, CNRS UMR 5293, Bordeaux, France;
Université Victor Segalen Bordeaux 2, Bordeaux, France; Pôle Universitaire de
Psychiatrie Adulte, Hôpital Charles Perrens, Bordeaux, France. Electronic
address: .
(2)Institut des Maladies Neurodégénératives, CNRS UMR 5293, Bordeaux, France;
Université Victor Segalen Bordeaux 2, Bordeaux, France.
(3)Université Victor Segalen Bordeaux 2, Bordeaux, France; Institut des
Neurosciences Cognitives et Intégratives d’Aquitaine, CNRS UMR 5287, Bordeaux,
France.
(4)Université Victor Segalen Bordeaux 2, Bordeaux, France; Institut des
Neurosciences Cognitives et Intégratives d’Aquitaine, CNRS UMR 5287, Bordeaux,
France; Service de Médecine Nucléaire, Hôpital Pellegrin, Bordeaux, France.
(5)Institut des Maladies Neurodégénératives, CNRS UMR 5293, Bordeaux, France;
Université Victor Segalen Bordeaux 2, Bordeaux, France; Service de
Neurophysiologie, Hôpital Pellegrin, Bordeaux, France.
(6)Université Victor Segalen Bordeaux 2, Bordeaux, France.
(7)Centre d’Investigation Clinique, INSERM U 802, Poitiers, France; INSERM U
1084, Laboratoire de Neurosciences Expérimentales et Cliniques, Equipe AVENIR ≪
Psychobiologie des Troubles Compulsifs ≫, Poitiers, France; Université de
Poitiers, Poitiers, France; Centre Hospitalier Universitaire, Poitiers, France;
Unité de Recherche Clinique Intersectorielle en Psychiatrie, Hôpital Henri
Laborit, Poitiers, France.
(8)Université Victor Segalen Bordeaux 2, Bordeaux, France; Pôle Universitaire de
Psychiatrie Adulte, Hôpital Charles Perrens, Bordeaux, France.
INTRODUCTION: Behavioral adaptation generally follows the contextual changes
arising from the consequences (rewards and punishments) of an action. According
to the reciprocal determinism model, there is a mutual influence between
external context, cognitive processes and behavior. The maladaptive behaviors
observed in obsessive-compulsive disorder (OCD) have been hypothesized to result
from the disruption of the interactions between these three entities. For this,
we assessed the influence of error signals and checking behavior on prefrontal
cortical functions during decision-making in 14 OCD patients and 14 matched
healthy participants.
METHODS: We used a behavioral task designed to elicit intolerance of uncertainty
(IU) followed by the free expression of checking behaviors, which was coupled
with functional magnetic resonance imaging.
RESULTS: At the behavioral level, IU intensity was correlated to the number of
checking behaviors in both checking OCD patients and healthy controls during
decision-making. However, external error signals did not influence checking
behaviors in OCD patients, whereas they appeared to trigger checking behaviors
in healthy subjects. At the neural level, IU intensity was positively correlated
with activation in the orbitofrontal cortex (OFC) in both the OCD and control
groups. At the region of interest (ROI) level, error signals increased
IU-related OFC activations; in contrast, checking behaviors contributed to
decreasing these neural activations in the healthy subjects, but no such
modulation was observed in the OCD patients.
CONCLUSIONS: Our results show that IU-related OFC dysfunctions are not under the
influence of the context and the behavioral response in OCD, suggesting that
alterations of the dynamic features for this neural network may contribute to
the expression of OCD symptoms.
Copyright © 2012 Elsevier Ltd. All rights reserved.
DOI: 10.1016/j.cortex.2012.12.010
PMID: 23318087 [Indexed for MEDLINE]