Relationship between body mass index and neuropsychiatric symptoms: Evidence and inflammatory correlates.
Brain, Behavior, and Immunity. 2021-05-01; 94: 104-110
DOI: 10.1016/j.bbi.2021.02.031
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Huet L(1), Delgado I(1), Dexpert S(1), Sauvant J(1), Aouizerate B(2), Beau C(3),
Forestier D(3), Ledaguenel P(3), Magne E(3), Capuron L(4).
Author information:
(1)Univ. Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, F-33000 Bordeaux,
France.
(2)Univ. Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, F-33000 Bordeaux,
France; Centre de Référence Régional des Pathologies Anxieuses et de la
Dépression, Hôpital Charles Perrens, F-33076 Bordeaux, France.
(3)Service de Chirurgie Digestive et Pariétale, Clinique Tivoli, F-33000
Bordeaux, France; Service de Chirurgie Digestive et Pariétale, Clinique Jean
Villar, F-33520 Bruges, France.
(4)Univ. Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, F-33000 Bordeaux,
France. Electronic address: .
OBJECTIVE: Neuropsychiatric symptoms are frequent in obese individuals. Mounting
evidence suggests that adiposity-related inflammation contributes to this
effect. This study assessed the relationship between adiposity, neuropsychiatric
symptom dimensions and systemic inflammation in subjects stratified by
body-mass-index (BMI).
METHODS: The study included 165 subjects, of whom 70 were very severely obese
(BMI ≥ 40 kg/m2), 50 severely obese (BMI: 35-39.99 kg/m2), 21 overweight or
moderately obese (BMI: 25-34.9 kg/m2), and 24 lean (BMI