Direct medical cost of bipolar disorder: Insights from the FACE-BD longitudinal cohort.
Journal of Affective Disorders. 2022-06-01; 306: 223-231
DOI: 10.1016/j.jad.2022.02.071
Lire sur PubMed
1. J Affect Disord. 2022 Jun 1;306:223-231. doi: 10.1016/j.jad.2022.02.071. Epub
2022 Mar 3.
Direct medical cost of bipolar disorder: Insights from the FACE-BD longitudinal
cohort.
Laidi C(1), Godin O(2), Etain B(3), Bellivier F(4), Elandaloussi Y(5), Olié
E(6), Aouizerate B(7), Gard S(8), Loftus J(9), Belzeaux R(10), Dubertret C(11),
Laouamri H(12), Passerieux C(13), Pelletier A(14), Polosan M(15), Schwan R(16),
Samalin L(17), Llorca PM(18), Courtet P(19); FondaMental Advanced Center of
Expertise for Bipolar Disorders (FACE-BD) collaborators; Durand-Zaleski I(20),
Leboyer M(21).
Author information:
(1)Univ Paris Est Créteil, INSERM U955, IMRB, Translational Neuro-Psychiatry,
F-94010 Créteil, France; AP-HP, Hôpitaux Universitaires Henri Mondor,
Département Médico-Universitaire de Psychiatrie et d’Addictologie (DMU IMPACT),
Fédération Hospitalo-Universitaire de Médecine de Précision en Psychiatrie (FHU
ADAPT), F-94010, France; Fondation FondaMental, F-94010 Créteil, France; Child
Mind Institute, New York, USA. Electronic address: .
(2)Univ Paris Est Créteil, INSERM U955, IMRB, Translational Neuro-Psychiatry,
F-94010 Créteil, France; AP-HP, Hôpitaux Universitaires Henri Mondor,
Département Médico-Universitaire de Psychiatrie et d’Addictologie (DMU IMPACT),
Fédération Hospitalo-Universitaire de Médecine de Précision en Psychiatrie (FHU
ADAPT), F-94010, France; Fondation FondaMental, F-94010 Créteil, France.
Electronic address: .
(3)Fondation FondaMental, F-94010 Créteil, France; Université de Paris, Paris,
France; AP-HP, Groupe Hospitalo-universitaire AP-HP Nord, DMU Neurosciences,
Hôpital Fernand Widal, Département de Psychiatrie et de Médecine Addictologique,
Paris, France; INSERM UMRS 1144, Paris, France. Electronic address:
.
(4)Fondation FondaMental, F-94010 Créteil, France; Université de Paris, Paris,
France; AP-HP, Groupe Hospitalo-universitaire AP-HP Nord, DMU Neurosciences,
Hôpital Fernand Widal, Département de Psychiatrie et de Médecine Addictologique,
Paris, France; INSERM UMRS 1144, Paris, France. Electronic address:
.
(5)AP-HP, Hôpitaux Universitaires Henri Mondor, Département Médico-Universitaire
de Psychiatrie et d’Addictologie (DMU IMPACT), Fédération
Hospitalo-Universitaire de Médecine de Précision en Psychiatrie (FHU ADAPT),
F-94010, France. Electronic address: .
(6)Fondation FondaMental, F-94010 Créteil, France; Department of Emergency
Psychiatry and Acute Care, CHU Montpellier, IGF, Univ. Montpellier, CNRS,
INSERM, Montpellier, France. Electronic address: .
(7)Fondation FondaMental, F-94010 Créteil, France; NutriNeuro, INRAE UMR 1286,
University of Bordeaux, Bordeaux F-33076, France; Pôle de Psychiatrie Générale
et Universitaire, Centre Hospitalier Charles Perrens, Bordeaux F-33076, France.
Electronic address: .
(8)Fondation FondaMental, F-94010 Créteil, France; Pôle de Psychiatrie Générale
et Universitaire, Centre Hospitalier Charles Perrens, Bordeaux F-33076, France.
Electronic address: .
(9)Fondation FondaMental, F-94010 Créteil, France; Pôle de Psychiatrie, Centre
Hospitalier Princesse Grace, Monaco. Electronic address:
.
(10)Fondation FondaMental, F-94010 Créteil, France; Pôle de Psychiatrie,
Assistance Publique Hôpitaux de Marseille, Marseille, France; INT-UMR7289, CNRS
Aix-Marseille Université, Marseille, France. Electronic address:
.
(11)Fondation FondaMental, F-94010 Créteil, France; Université de Paris, INSERM
UMR1266, AP-HP, Groupe Hospitalo-Universitaire AP-HP Nord, service de
Psychiatrie et Addictologie. Hôpital Louis Mourier, Colombes, France. Electronic
address: .
(12)Fondation FondaMental, F-94010 Créteil, France. Electronic address:
.
(13)Fondation FondaMental, F-94010 Créteil, France; Service Universitaire de
psychiatrie et d’addictologie du Centre Hospitalier de Versailles, INSERM
UMR1018, CESP, Team « DevPsy », Université de Versailles
Saint-Quentin-en-Yvelines, Paris -Saclay, France. Electronic address:
.
(14)Univ Paris Est Créteil, INSERM U955, IMRB, Translational Neuro-Psychiatry,
F-94010 Créteil, France; AP-HP, Hôpitaux Universitaires Henri Mondor,
Département Médico-Universitaire de Psychiatrie et d’Addictologie (DMU IMPACT),
Fédération Hospitalo-Universitaire de Médecine de Précision en Psychiatrie (FHU
ADAPT), F-94010, France; Fondation FondaMental, F-94010 Créteil, France.
Electronic address: .
(15)Fondation FondaMental, F-94010 Créteil, France; Université Grenoble Alpes,
CHU de Grenoble et des Alpes, Grenoble Institut des Neurosciences (GIN) Inserm U
1216, Grenoble, France. Electronic address: .
(16)Fondation FondaMental, F-94010 Créteil, France; Université de Lorraine,
Inserm U 1254, Pôle Hospitalo-Universitaire de Psychiatrie d’Adultes et
d’Addictologie CPN Laxou, France. Electronic address:
.
(17)Fondation FondaMental, F-94010 Créteil, France; CHU Clermont-Ferrand,
Department of Psychiatry, University of Clermont Auvergne, CNRS, Clermont
Auvergne INP, Institut Pascal, 63000 Clermont-Ferrand, France. Electronic
address: .
(18)Fondation FondaMental, F-94010 Créteil, France; CHU Clermont-Ferrand,
Department of Psychiatry, University of Clermont Auvergne, CNRS, Clermont
Auvergne INP, Institut Pascal, 63000 Clermont-Ferrand, France. Electronic
address: .
(19)Fondation FondaMental, F-94010 Créteil, France; Department of Emergency
Psychiatry and Acute Care, CHU Montpellier, IGF, Univ. Montpellier, CNRS,
INSERM, Montpellier, France. Electronic address:
.
(20)AP-HP Health Economics Research Unit, Hotel Dieu Hospital, INSERM UMR 1153
CRESS, Paris, France.
(21)Univ Paris Est Créteil, INSERM U955, IMRB, Translational Neuro-Psychiatry,
F-94010 Créteil, France; AP-HP, Hôpitaux Universitaires Henri Mondor,
Département Médico-Universitaire de Psychiatrie et d’Addictologie (DMU IMPACT),
Fédération Hospitalo-Universitaire de Médecine de Précision en Psychiatrie (FHU
ADAPT), F-94010, France; Fondation FondaMental, F-94010 Créteil, France.
BACKGROUND: Bipolar disorder (BD) is a severe chronic psychiatric disorder
affecting 0.5 to 1% of the population worldwide. To date, most studies have
estimated the cost of BD via information sourced from insurance claims with
limited information on clinical characteristics and course of BD. The aims of
this study are (i) to estimate the direct healthcare cost associated with BD and
to identify contributing factors and (ii) to study the evolution of cost during
a two-year follow-up period.
METHOD: We analyzed a sample of 1116 individuals with BD included in the
Advanced Centers of Expertise in Bipolar Disorder cohort. We estimated the
direct healthcare cost per year and per patient, and we identified the clinical
features of patients with BD associated with higher direct healthcare costs. In
a subsample of patients followed up for two years centers of expertise for BD,
we studied the evolution of direct healthcare cost.
RESULTS: The average cost of bipolar disorder was € 6910 per year and per
patient. Clinical features of BD, sociodemographic characteristics, and
associated addiction were associated with higher direct healthcare costs. In the
subsample of patients followed-up for two years, direct healthcare cost dropped
by more than 50%, strongly suggesting the beneficial effect of specialized care
organization.
LIMITATION: We did not estimate indirect healthcare and intangible costs.
CONCLUSION: Our study investigates the cost of BD and its evolution in a deeply
phenotyped longitudinal sample. Cost-utility and cost-effectiveness analyses are
required to inform resource allocation decisions and to promote innovative
healthcare organizations.
Copyright © 2022. Published by Elsevier B.V.
DOI: 10.1016/j.jad.2022.02.071
PMID: 35248665 [Indexed for MEDLINE]