Crossed clinical features between eating disorders and types of bipolar disorder: Results from the FondaMental Advanced Centers of Expertise – Bipolar Disorder cohort.
Journal of Affective Disorders. 2023-08-01; 335: 177-185
DOI: 10.1016/j.jad.2023.05.017
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1. J Affect Disord. 2023 Aug 15;335:177-185. doi: 10.1016/j.jad.2023.05.017. Epub
2023 May 12.
Crossed clinical features between eating disorders and types of bipolar
disorder: Results from the FondaMental Advanced Centers of Expertise – Bipolar
Disorder cohort.
Flaudias V(1), Samalin L(2), Godin O(3), Gard S(4), Brousse G(2), Loftus J(5),
Aubin V(5), Belzeaux R(6), Dubertret C(7), Le Strat Y(7), Mazer N(7), de
Prémorel A(7), Roux P(8), Polosan M(9), Schwitzer T(10), Aouizerate B(4), Llorca
PM(2); FondaMental Advanced Centers of Expertise for Bipolar Disorder (FACE-BD)
collaborators(11); Biseul I(11), Etain B(12), Moirand R(13), Olié E(14), Haffen
E(15), Leboyer M(16), Courtet P(17), Icick R(12), Guillaume S(14).
Author information:
(1)Nantes Université, Univ Angers, Laboratoire de psychologie des Pays de la
Loire, LPPL, UR 4638, Nantes, France; CHU Clermont-Ferrand, Department of
Psychiatry, Clermont-Ferrand, France; CHU Clermont-Ferrand, Department of
Psychiatry, University of Clermont Auvergne, CNRS, Clermont Auvergne INP,
Institut Pascal, 63000 Clermont-Ferrand, France. Electronic address:
.
(2)FondaMental Foundation, Créteil F-94000, France; CHU Clermont-Ferrand,
Department of Psychiatry, University of Clermont Auvergne, CNRS, Clermont
Auvergne INP, Institut Pascal, 63000 Clermont-Ferrand, France.
(3)FondaMental Foundation, Créteil F-94000, France.
(4)FondaMental Foundation, Créteil F-94000, France; Pôle de Psychiatrie Générale
et Universitaire, Center Hospitalier Charles Perrens, France NutriNeuro, INRAE
UMR 1286, University of Bordeaux, Bordeaux F-33076, France.
(5)FondaMental Foundation, Créteil F-94000, France; Pôle de Psychiatrie, Center
Hospitalier Princesse Grace, Monaco.
(6)FondaMental Foundation, Créteil F-94000, France; Pôle de Psychiatrie,
Assistance Publique Hôpitaux de Marseille, INT-UMR7289, CNRS Aix-Marseille
Université, Marseille, France.
(7)FondaMental Foundation, Créteil F-94000, France; Université de Paris, INSERM
UMR1266, AP-HP, Groupe Hospitalo-Universitaire AP-HP Nord, service de
Psychiatrie et Addictologie, Hôpital Louis Mourier, Colombes, France.
(8)FondaMental Foundation, Créteil F-94000, France; Centre Hospitalier de
Versailles, Service Universitaire de Psychiatrie de l’Enfant et de l’Adolescent,
Le Chesnay, Université Paris-Saclay, Université de Versailles
Saint-Quentin-En-Yvelines, DisAP-DevPsy-CESP, INSERM UMR1018, Villejuif, France.
(9)FondaMental Foundation, Créteil F-94000, France; Université Grenoble Alpes,
CHU de Grenoble et des Alpes, Grenoble Institut des Neurosciences (GIN) Inserm U
1216, Grenoble, France.
(10)FondaMental Foundation, Créteil F-94000, France; Université de Lorraine,
Inserm U 1254, Pôle Hospitalo-Universitaire de Psychiatrie d’Adultes et
d’Addictologie CPN, Laxou, France.
(11)FondaMental Foundation, Créteil F-94000, France; AP-HP.Nord, Groupe
Hospitalo-universitaire Lariboisière-Fernand Widal, DMU Neurosciences,
Département de Psychiatrie et de Médecine Addictologique, Paris F-75010, France.
(12)FondaMental Foundation, Créteil F-94000, France; AP-HP.Nord, Groupe
Hospitalo-universitaire Lariboisière-Fernand Widal, DMU Neurosciences,
Département de Psychiatrie et de Médecine Addictologique, Paris F-75010, France;
INSERM UMRS 1144, Université de Paris Cité, Paris F-75006, France.
(13)FondaMental Foundation, Créteil F-94000, France; INSERM U1028, CNRS UMR5292,
University Lyon 1, Villeurbanne F-69000, France; Lyon Neuroscience Research
Center, Psychiatric Disorders: from Resistance to Response ΨR2 Team, Centre
Hospitalier Le Vinatier, F-69678, France.
(14)FondaMental Foundation, Créteil F-94000, France; Department of Emergency
Psychiatry and Acute Care, Lapeyronie Hospital CHU, Montpellier, France;
Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM,
Montpellier, France.
(15)Service de Psychiatrie de l’Adulte, CIC-1431 INSERM, CHU de Besançon,
Laboratoire de Recherche Intégratives en Neurosciences et Psychologie Cognitive,
Université de Franche-Comté, Besançon, France.
(16)FondaMental Foundation, Créteil F-94000, France; AP-HP, Hôpitaux
Universitaires Henri Mondor, Département Médico-Universitaire de Psychiatrie et
d’Addictologie (DMU IMPACT), Fédération Hospitalo-Universitaire de Médecine de
Précision en Psychiatrie (FHU ADAPT), Université Paris Est Créteil, INSERM U955,
F-94010, France.
(17)FondaMental Foundation, Créteil F-94000, France; Department of Emergency
Psychiatry and Acute Care, Lapeyronie Hospital CHU, Montpellier, France.
BACKGROUND: Eating disorders (EDs) are liable to alter the disease course of
bipolar disorder (BD). We explored the crossed clinical features between EDs and
BD, particularly as a function of BD type (BD1 vs. BD2).
METHODS: 2929 outpatients attending FondaMental Advanced Centers of Expertise
were assessed for BD and lifetime EDs with a semi-structured interview, and
their sociodemographic, dimensional and clinical data were collected according
to a standardized procedure. For each ED type, bivariate analyses were used to
investigate associations between these variables and the type of BD type
followed by multinomial regressions with the variables associated with EDs and
BDs after Bonferroni correction.
RESULTS: Comorbid EDs were diagnosed in 478 (16.4 %) cases, and were more
prevalent in patients with BD2 than in those with BD1 (20.6 % vs. 12.4 %,
p