Indirect effect of impulsivity on suicide risk through self-esteem and depressive symptoms in a population with treatment-resistant depression: A FACE-DR study.
Journal of Affective Disorders. 2024-02-01; 347: 306-313
DOI: 10.1016/j.jad.2023.11.063
Lire sur PubMed
1. J Affect Disord. 2024 Feb 15;347:306-313. doi: 10.1016/j.jad.2023.11.063. Epub
2023 Nov 20.
Indirect effect of impulsivity on suicide risk through self-esteem and
depressive symptoms in a population with treatment-resistant depression: A
FACE-DR study.
Salles J(1), Stephan F(2), Molière F(3), Bennabi D(4), Haffen E(4), Bouvard
A(5), Walter M(2), Allauze E(6), Llorca PM(6), Genty JB(7), Leboyer M(7),
Holtzmann J(8), Nguon AS(8), D’Amato T(9), Rey R(9), Horn M(10), Vaiva G(11),
Fond G(12), Richieri R(13), Hennion V(14), Etain B(15), El-Hage W(16), Camus
V(16); FondaMental Advanced Centers of Expertise in Resistant Depression
(FACE-DR) collaborators; Courtet P(3), Aouizerate B(5), Yrondi A(17).
Author information:
(1)Fondation FondaMental (FondaMental Foundation), Créteil, France; Service des
urgences psychiatriques, Infinity (Infinity, Department of Emergency
Psychiatry), INSERM UMR1291, CNRS UMR5051, Centre Hospitalier Universitaire de
Toulouse (Toulouse University Hospital), Toulouse, France.
(2)Fondation FondaMental (FondaMental Foundation), Créteil, France; Service
Hospitalo-Universitaire de Psychiatrie Générale et de Réhabilitation Psycho
Sociale 29G01 et 29G02 (University Hospital Department of General Psychiatry and
Psycho-Social Rehabilitation 29G01 and 29G02), Centre Expert Depression
Résistante FondaMental (Fondaental Expert Centre for Resistant Depression), EA
7479, CHRU de Brest (Brest Regional University Hospital), Hôpital de Bohars
(Bohars Hospital), Brest, France.
(3)Fondation FondaMental (FondaMental Foundation), Créteil, France; Department
of Emergency Psychiatry and Acute Care, CHU Montpellier (Montpellier University
Hospital), INSERM U1061, Montpellier University, Montpellier, France.
(4)Fondation FondaMental (FondaMental Foundation), Créteil, France; Service de
Psychiatrie (Department of Psychiatry), Centre Expert Dépression Résistante
FondaMental (FondaMental Expert Centre for Resistant Depression), CIC-1431
INSERM, CHU de Besançon (Besançon University Hospital), EA 481 Neurosciences,
Université de Bourgogne Franche Comté, Besançon, France.
(5)Fondation FondaMental (FondaMental Foundation), Créteil, France; Pôle de
Psychiatrie Générale et Universitaire (General and University Psychiatry Unit),
Centre de référence régional des pathologies anxieuses et de la dépression
(Regional Reference Centre for Anxiety and Depression-Related Disorders), Centre
Expert Dépression Résistante FondaMental, CH Charles Perrens, Bordeaux,
Laboratoire Nutrition et Neurobiologie intégrée (Integrated Nutrition and
Neurobiology Laboratory) (UMR INRAE 1286), Université de Bordeaux, Bordeaux,
France.
(6)Fondation FondaMental (FondaMental Foundation), Créteil, France; Department
of Psychiatry, CHU Clermont-Ferrand, University of Clermont Auvergne, EA 7280
Clermont-Ferrand, France.
(7)Fondation FondaMental (FondaMental Foundation), Créteil, France; Université
Paris-Est, UMR_S955, UPEC, Créteil, France Inserm, U955, Equipe 15 Psychiatrie
génétique (Team 15 Genetic Psychiatry), Créteil, France AP-HP, Hôpital H.
Mondor-A. Chenevier, Pôle de psychiatrie (Psychiatry Unit), Créteil, France
Fondation FondaMental, Fondation de Cooperation Scientifique (Foundation for
Scientific Cooperation), Créteil, France.
(8)Fondation FondaMental (FondaMental Foundation), Créteil, France; Service de
Psychiatrie de l’adulte (Department of Adult Psychiatry), Centre Expert
Dépression Résistante FondaMental, CHU de Grenoble-Alpes, Hôpital Nord,
Grenoble, CS 10217, France.
(9)Fondation FondaMental (FondaMental Foundation), Créteil, France; INSERM
U1028, CNRS UMR5292, University Lyon 1, Lyon Neuroscience Research Centre,
Psychiatric Disorders: from Resistance to Response ΨR2 Team, Centre Hospitalier
Le Vinatier, Bron, France.
(10)Fondation FondaMental (FondaMental Foundation), Créteil, France; Service de
Psychiatrie adulte (Department of Adult Psychiatry), Centre Expert Dépression
Résistante FondaMental, CHRU de Lille, Hôpital Fontan 1, Lille, France.
(11)Fondation FondaMental (FondaMental Foundation), Créteil, France; Service de
Psychiatrie adulte (Department of Adult Psychiatry), Centre Expert Dépression
Résistante FondaMental, CHRU de Lille, Hôpital Fontan 1, Lille, France; Centre
National de Ressources et Résilience pour les psychotraumatismes (National
Psychological Trauma Resource and Resilience Centre) (Cn2r Lille Paris), Lille,
France.
(12)Fondation FondaMental (FondaMental Foundation), Créteil, France; Faculté de
Médecine (Faculty of Medicine), Marseille Univ, EA 3279, Service d’Épidémiologie
et d’Économie de la Santé (Department of Epidemiology and Health Economics),
Marseille, France.
(13)Fondation FondaMental (FondaMental Foundation), Créteil, France; Pôle
Psychiatrie (Psychiatry Unit), Centre Expert Dépression Résistante FondaMental,
CHU La Conception, Marseille, France.
(14)Fondation FondaMental (FondaMental Foundation), Créteil, France; Département
de Psychiatrie et de Médecine Addictologique (Department of Psychiatry and
Addiction Medicine), Lariboisière-Fernand Widal GHU APHP Nord Université Paris
cité Paris, France.
(15)Fondation FondaMental (FondaMental Foundation), Créteil, France; Département
de Psychiatrie et de Médecine Addictologique (Department of Psychiatry and
Addiction Medicine), Lariboisière-Fernand Widal GHU APHP Nord Université Paris
cité Paris, France; Université Paris Cité, INSERM UMR-S 1144, Optimisation
Thérapeutique en Neurospsychopharmacologie (Therapeutic Optimisation in
Neuropsychopharmacology), OTeN, F-75006 Paris, France.
(16)Fondation FondaMental (FondaMental Foundation), Créteil, France; U1253,
iBrain, CIC1415, Inserm, Pôle psychiatrie-Addictologie, (Psychiatry-Addiction
Unit) CHRU de Tours, Université de Tours, Tours, France.
(17)Fondation FondaMental (FondaMental Foundation), Créteil, France; Service de
Psychiatrie et de Psychologie Médicale (Department of Psychiatry and Medical
Psychology), Centre Expert Dépression Résistante FondaMental, CHU de Toulouse,
Hôpital Purpan, ToNIC Toulouse NeuroImaging Centre, Université de Toulouse,
INSERM, UPS, Toulouse, France. Electronic address: .
INTRODUCTION: Suicide is a major health issue. Its prevalence is particularly
high in subjects presenting major depression disorder (MDD), making this a key
suicide-related risk factor. Suicide attempts in severe forms of MDD were
assumed to be linked to impulsivity and loss of control. Nevertheless, we failed
to find data specifically investigating the link between impulsivity and suicide
risk in treatment-resistant depression (TRD). This study seeks to review this
relationship.
METHOD: Patients were recruited for a prospective cohort. Suicide risk and
impulsivity were assessed using the International Neuropsychiatric Interview and
Barratt Impulsiveness Scale, Version 10, respectively, while the severity of
depressive symptoms was assessed using the Montgomery-Asberg Depression Rating
Scale, anxiety with the State-Trait Anxiety Inventory and childhood maltreatment
using the Childhood Trauma Questionnaire.
RESULTS: 220 TRD patients were enrolled in the study. The impulsivity score was
correlated with self-esteem, marital status, professional status and anxiety.
There was no direct link to suicide risk. However, impulsivity was associated
with self-esteem (coefficient: -0.24; p value 0.043) and depressive symptom
severity (coefficient: 0.; p value 0.045). The suicide risk was significantly
correlated with depressive symptom severity (coefficient = 0.38, p