Cord serum cytokines at birth and children’s trajectories of mood dysregulation symptoms from 3 to 8 years: The EDEN birth cohort.
Brain, Behavior, & Immunity - Health. 2024-07-01; 38: 100768
DOI: 10.1016/j.bbih.2024.100768
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1. Brain Behav Immun Health. 2024 Mar 29;38:100768. doi:
10.1016/j.bbih.2024.100768. eCollection 2024 Jul.
Cord serum cytokines at birth and children’s trajectories of mood dysregulation
symptoms from 3 to 8 years: The EDEN birth cohort.
Herbein M(1)(2)(3), Barbosa S(4)(5), Collet O(1)(6), Khalfallah O(4)(5), Navarro
M(1)(2), Bailhache M(1)(2)(7), Iv N(1)(2), Aouizerate B(1)(3)(8), Sutter-Dallay
AL(2)(3), Koehl M(1)(9), Capuron L(1)(8), Ellul P(10)(11), Peyre H(10)(12)(13),
Van der Waerden J(14), Melchior M(14), Côté S(1)(2)(6)(15), Heude B(16)(17),
Glaichenhaus N(4)(5)(18), Davidovic L(4)(5)(18), Galera C(1)(2)(3)(6).
Author information:
(1)University of Bordeaux, France.
(2)INSERM, Bordeaux Population Health Center, UMR1219, France.
(3)Centre Hospitalier Perrens, Bordeaux, France.
(4)Université Côte d’Azur, Nice, France.
(5)Centre National de Recherche Scientifique, Institut de Pharmacologie
Moléculaire et Cellulaire, Valbonne, France.
(6)Research Unit on Children’s Psychosocial Maladjustment, Montreal, Canada.
(7)Centre Hospitalier Universitaire de Bordeaux, Département de Pédiatrie,
France.
(8)INRAE, Bordeaux INP, NutriNeuro, UMR 1286, Bordeaux, France.
(9)INSERM, Neurocentre Magendie, UMR1215, Bordeaux, France.
(10)Robert Debré Hospital, Child and Adolescent department, APHP, Paris
University, Paris, France.
(11)Immunology-Immunopathology-Immunotherapy (i3), UMRS 959, INSERM, Paris,
France.
(12)Centre de Ressource Autisme Languedoc-Roussillon et Centre d’Excellence sur
l’Autisme et les Troubles du Neurodéveloppement (CeAND), CHU Montpellier,
Montpellier, France.
(13)Université Paris Saclay, UVSQ, Inserm, CESP, Tem DevPsy, 94807, Villejuif,
France.
(14)INSERM U1136, Institut Pierre Louis d’Epidémiologie et de Santé Publique,
Sorbonne Université, Équipe de Recherche en Épidémiologie Sociale, Paris,
France.
(15)University of Montreal, Department of Social and Preventive Medicine,
Montreal, Canada.
(16)Université de Paris, Centre for Research in Epidemiology and Statistics
(CRESS), INSERM, INRAE, F-75004, Paris, France.
(17)Paris University, France.
(18)Fondation FondaMental, Créteil, France.
There is growing evidence that in utero imbalance immune activity plays a role
in the development of neurodevelopmental and psychiatric disorders in children.
Mood dysregulation (MD) is a debilitating transnosographic syndrome whose
underlying pathophysiological mechanisms could be revealed by studying its
biomarkers using the Research Domain Criteria (RDoC) model. Our aim was to study
the association between the network of cord serum cytokines, and mood
dysregulation trajectories in offsprings between 3 and 8 years of age. We used
the data of a study nested in the French birth cohort EDEN that took place from
2003 to 2014 and followed mother-child dyads from the second trimester of
pregnancy until the children were 8 years of age. The 2002 mother-child dyads
were recruited from the general population through their pregnancy follow-up in
two French university hospitals. 871 of them were included in the nested cohort
and cord serum cytokine levels were measured at birth. Children’s mood
dysregulation symptoms were assessed with the Strengths and Difficulties
Questionnaire Dysregulation Profile at the ages 3, 5 and 8 years in order to
model their mood dysregulation trajectories. Out of the 871 participating dyads,
53% of the children were male. 2.1% of the children presented a high mood
dysregulation trajectory whereas the others were considered as physiological
variations. We found a significant negative association between TNF-α cord serum
levels and a high mood dysregulation trajectory when considering confounding
factors such as maternal depression during pregnancy (adjusted Odds Ratio
(aOR) = 0.35, 95% Confidence Interval (CI) [0.18-0.67]). Immune imbalance at
birth could play a role in the onset of mood dysregulation symptoms. Our
findings throw new light on putative immune mechanisms implicated in the
development of mood dysregulation and should lead to future animal and
epidemiological studies.
© 2024 The Authors. Published by Elsevier Inc.
DOI: 10.1016/j.bbih.2024.100768
PMCID: PMC10990861
PMID: 38586283
Conflict of interest statement: We declare none of the authors has any conflict
of interest regarding the manuscript “Cord serum cytokines at birth and
children’s trajectories of mood dysregulation symptoms from 3 to 8 years: the
EDEN birth cohort”