Olfactory bulb astrocytes link social transmission of stress to cognitive adaptation in male mice
Nat Commun. 2024-08-18; 15(1):
DOI: 10.1038/s41467-024-51416-4
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Gómez-Sotres P(1), Skupio U(1), Dalla Tor T(1)(2), Julio-Kalajzic F(1), Cannich
A(1), Gisquet D(1), Bonilla-Del Rio I(2)(3), Drago F(4), Puente N(2)(3), Grandes
P(2)(3), Bellocchio L(1), Busquets-Garcia A(5), Bains JS(6)(7), Marsicano G(8).
Author information:
(1)Universite de Bordeaux, INSERM, U1215 Neurocentre Magendie, Bordeaux, France.
(2)Department of Neurosciences, Faculty of Medicine and Nursing, University of
the Basque Country UPV/EHU, E-48940, Leioa, Spain.
(3)Achucarro Basque Center for Neuroscience, Science Park of the UPV/EHU, Leioa,
Spain.
(4)Department of Biomedical and Biotechnological Sciences, Section of
Pharmacology, University of Catania, Catania, 95124, Italy.
(5)IMIM-Hospital del Mar Medical Research Institute, PRBB, Barcelona, Spain.
(6)Krembil Brain Institute, University Health Network, Toronto, ON, Canada.
.
(7)Hotchkiss Brain Institute and Department of Physiology & Pharmacology,
University of Calgary, Calgary, Canada. .
(8)Universite de Bordeaux, INSERM, U1215 Neurocentre Magendie, Bordeaux, France.
.
Emotions and behavior can be affected by social chemosignals from conspecifics.
For instance, olfactory signals from stressed individuals induce stress-like
physiological and synaptic changes in naïve partners. Direct stress also alters
cognition, but the impact of socially transmitted stress on memory processes is
currently unknown. Here we show that exposure to chemosignals produced by
stressed individuals is sufficient to impair memory retrieval in unstressed male
mice. This requires astrocyte control of information in the olfactory bulb
mediated by mitochondria-associated CB1 receptors (mtCB1). Targeted genetic
manipulations, in vivo Ca2+ imaging and behavioral analyses reveal that
mtCB1-dependent control of mitochondrial Ca2+ dynamics is necessary to process
olfactory information from stressed partners and to define their cognitive
consequences. Thus, olfactory bulb astrocytes provide a link between social
odors and their behavioral meaning.
© 2024. The Author(s).
Conflict of interest statement: The authors declare no competing interests.