Incomplete Hippocampal Inversion: A Comprehensive MRI Study of Over 2000 Subjects.

Claire Cury, Roberto Toro, Fanny Cohen, Clara Fischer, Amel Mhaya, Jorge Samper-González, Dominique Hasboun, Jean-François Mangin, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg, Christian Buechel, Anna Cattrell, Patricia Conrod, Herta Flor, Juergen Gallinat, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Hervé Lemaitre, Jean-Luc Martinot, Frauke Nees, Marie-Laure Paillère Martinot, Dimitri P. Orfanos, Tomas Paus, Luise Poustka, Michael N. Smolka, Henrik Walter, Robert Whelan, Vincent Frouin, Gunter Schumann, Joan A. Glaunès, Olivier Colliot
Front. Neuroanat.. 2015-12-22; 9:
DOI: 10.3389/fnana.2015.00160


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The incomplete-hippocampal-inversion (IHI), also known as malrotation, is an
atypical anatomical pattern of the hippocampus, which has been reported in
healthy subjects in different studies. However, extensive characterization of IHI
in a large sample has not yet been performed. Furthermore, it is unclear whether
IHI are restricted to the medial-temporal lobe or are associated with more
extensive anatomical changes. Here, we studied the characteristics of IHI in a
community-based sample of 2008 subjects of the IMAGEN database and their
association with extra-hippocampal anatomical variations. The presence of IHI was
assessed on T1-weighted anatomical magnetic resonance imaging (MRI) using visual
criteria. We assessed the association of IHI with other anatomical changes
throughout the brain using automatic morphometry of cortical sulci. We found that
IHI were much more frequent in the left hippocampus (left: 17%, right: 6%,
χ(2)-test, p < 10(-28)). Compared to subjects without IHI, subjects with IHI
displayed morphological changes in several sulci located mainly in the limbic
lobe. Our results demonstrate that IHI are a common left-sided phenomenon in
normal subjects and that they are associated with morphological changes outside
the medial temporal lobe.

Auteurs Bordeaux Neurocampus