White matter microstructure is associated with hyperactive/inattentive symptomatology and polygenic risk for attention-deficit/hyperactivity disorder in a population-based sample of adolescents

Matthew D. Albaugh, James. J. Hudziak, Alex Ing, Bader Chaarani, Edward Barker, Tianye Jia, Herve Lemaitre, Richard Watts, Catherine Orr, Philip A. Spechler, Claude Lepage, Vladimir Fonov, Louis Collins, Pierre Rioux, Alan C. Evans, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Vincent Frouin, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Juliane H. Fröhner, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Hugh Garavan, Alexandra Potter
Neuropsychopharmacol.. 2019-04-06; 44(9): 1597-1603
DOI: 10.1038/s41386-019-0383-y


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Few studies have investigated the link between putative biomarkers of
attention-deficit/hyperactivity disorder (ADHD) symptomatology and genetic risk
for ADHD. To address this, we investigate the degree to which ADHD symptomatology
is associated with white matter microstructure and cerebral cortical thickness in
a large population-based sample of adolescents. Critically, we then test the
extent to which multimodal correlates of ADHD symptomatology are related to ADHD
polygenic risk score (PRS). Neuroimaging, genetic, and behavioral data were
obtained from the IMAGEN study. A dimensional ADHD composite score was derived
from multi-informant ratings of ADHD symptomatology. Using tract-based spatial
statistics, whole brain voxel-wise regressions between fractional anisotropy (FA)
and ADHD composite score were calculated. Local cortical thickness was regressed
on ADHD composite score. ADHD PRS was based on a very recent genome-wide
association study, and calculated using PRSice. ADHD composite score was
negatively associated with FA in several white matter pathways, including
bilateral superior and inferior longitudinal fasciculi (p

Auteurs Bordeaux Neurocampus