IFN-alpha-induced motor slowing is associated with increased depression and fatigue in patients with chronic hepatitis C.
Brain, Behavior, and Immunity. 2008-08-01; 22(6): 870-880
DOI: 10.1016/j.bbi.2007.12.009
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1. Brain Behav Immun. 2008 Aug;22(6):870-80. doi: 10.1016/j.bbi.2007.12.009. Epub
2008 Feb 6.
IFN-alpha-induced motor slowing is associated with increased depression and
fatigue in patients with chronic hepatitis C.
Majer M(1), Welberg LA, Capuron L, Pagnoni G, Raison CL, Miller AH.
Author information:
(1)Department of Psychiatry and Behavioural Sciences, Winship Cancer Institute,
Emory University School of Medicine, 1365-C Clifton Road, Atlanta, GA 30322, USA.
Interferon (IFN)-alpha has been used to investigate pathways by which innate
immune cytokines influence the brain and behaviour. Previous studies suggest that
altered basal ganglia function may contribute to IFN-alpha-induced
neuropsychological and behavioural changes. To further examine IFN-alpha effects
on neuropsychological functions related to basal ganglia (as well as other brain
regions), and explore the relationship between altered neuropsychological
function and IFN-alpha-induced depression and fatigue, a selected subset of the
Cambridge Neuropsychological Test Automated Battery was administered to 32
hepatitis C patients at baseline (Visit 1) and following approximately 12 weeks
(Visit 2) of either no treatment (n=12) or treatment with IFN-alpha plus
ribavirin (n=20). Symptoms of depression and fatigue were assessed using the
Montgomery-Asberg Depression Rating Scale and the Multidimensional Fatigue
Inventory. Compared to control subjects, patients treated with
IFN-alpha/ribavirin exhibited significant decreases in motor speed as measured in
the simple and five-choice movement segments of the CANTAB reaction time task and
slower response times in the rapid visual information processing task, a task of
sustained attention. Decreased motor speed on the five-choice movement segments
of the reaction time task was in turn correlated with increased symptoms of
depression and fatigue (R=0.47, p